PMID- 10602418
OWN - NLM
STAT- MEDLINE
DCOM- 20000106
LR  - 20190915
IS  - 0887-6924 (Print)
IS  - 0887-6924 (Linking)
VI  - 13
IP  - 12
DP  - 1999 Dec
TI  - Fluorescence in situ hybridization analysis of chromosome 1 abnormalities in
      hematopoietic disorders: rearrangements of DNA satellite II and new recurrent
      translocations.
PG  - 1975-81
AB  - Using fluorescence in situ hybridization analysis, breakpoints involving the long
      arm of chromosome 1 (1q) were localized in 36 patients with various hematopoietic
      disorders and rearrangements of the proximal part of 1q, as ascertained with
      banding techniques. The breakpoint was localized within the satellite II (sat II)
      domain in 14 patients with various abnormalities, between the sat II domain and
      the BCL9 locus in eight, between the BCL9 and ARNT loci in two, between sat II
      and ARNT in two others, and distal to ARNT in seven. A dicentric chromosome 1 was
      present in two patients. A high incidence of heterochromatin heteromorphism of
      chromosome 1 was present in this series. Two recurrent translocations were
      identified, t(1;2)(q12;q37) in three patients suffering from three different
      acute leukemia subtypes, and t(1;16)(q12;q24) in two patients with different
      diseases. Two patients had jumping translocations. Most of the rearrangements of 
      1q were secondary abnormalities, included in complex karyotypes. The roles of
      methylation, interactions with the proteins interfering with heterochromatin and 
      possible gene silencing due to heterochromatin rearrangements are discussed.
FAU - Busson-Le Coniat, M
AU  - Busson-Le Coniat M
AD  - INSERM U434 and CNRS SD401 No. 434, CEPH, Institut de Genetique Moleculaire,
      Paris, France.
FAU - Salomon-Nguyen, F
AU  - Salomon-Nguyen F
FAU - Dastugue, N
AU  - Dastugue N
FAU - Maarek, O
AU  - Maarek O
FAU - Lafage-Pochitaloff, M
AU  - Lafage-Pochitaloff M
FAU - Mozziconacci, M J
AU  - Mozziconacci MJ
FAU - Baranger, L
AU  - Baranger L
FAU - Brizard, F
AU  - Brizard F
FAU - Radford, I
AU  - Radford I
FAU - Jeanpierre, M
AU  - Jeanpierre M
FAU - Bernard, O A
AU  - Bernard OA
FAU - Berger, R
AU  - Berger R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
RN  - 0 (DNA, Satellite)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Child, Preschool
MH  - *Chromosomes, Human, Pair 1
MH  - *DNA, Satellite
MH  - Female
MH  - *Gene Rearrangement
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Infant
MH  - Male
MH  - Middle Aged
MH  - Recurrence
MH  - *Translocation, Genetic
EDAT- 1999/12/22 00:00
MHDA- 1999/12/22 00:01
CRDT- 1999/12/22 00:00
PHST- 1999/12/22 00:00 [pubmed]
PHST- 1999/12/22 00:01 [medline]
PHST- 1999/12/22 00:00 [entrez]
AID - 10.1038/sj.leu.2401587 [doi]
PST - ppublish
SO  - Leukemia. 1999 Dec;13(12):1975-81. doi: 10.1038/sj.leu.2401587.