PMID- 10602049
OWN - NLM
STAT- MEDLINE
DCOM- 20000124
LR  - 20071115
IS  - 0014-2980 (Print)
IS  - 0014-2980 (Linking)
VI  - 30
IP  - 1
DP  - 2000 Jan
TI  - The chemokine TECK is expressed by thymic and intestinal epithelial cells and
      attracts double- and single-positive thymocytes expressing the TECK receptor
      CCR9.
PG  - 262-71
AB  - Chemokines are key regulators of migration in lymphoid tissues. In the thymus,
      maturing thymocytes move from the outer capsule to the inner medulla and thereby 
      interact with different types of stromal cells that control their maturation and 
      selection. In the process of searching for molecules specifically expressed at
      different stages of mouse thymic differentiation, we have characterized the cDNA 
      coding for the thymus-expressed chemokine (TECK) and its receptor CCR9. The TECK 
      receptor gene was isolated and shown to be localized on the mouse chromosome
      9F1-F4. Thymic dendritic cells have been initially thought to be a prevalent
      source of TECK. In contrast, our results indicate that thymic epithelial cells
      constitute the predominant source of TECK. Consistent with the latter
      distribution, the TECK receptor is highly expressed by double-positive
      thymocytes, and TECK can chemoattract both double-positive and single-positive
      thymocytes. The TECK transcript is also abundantly expressed in the epithelial
      cells lining the small intestine. In conclusion, the interplay of TECK and its
      receptor CCR9 is likely to have a significant role in the recruitment of
      developing thymocytes to discrete compartments of the thymus.
FAU - Wurbel, M A
AU  - Wurbel MA
AD  - Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Marseille, France.
FAU - Philippe, J M
AU  - Philippe JM
FAU - Nguyen, C
AU  - Nguyen C
FAU - Victorero, G
AU  - Victorero G
FAU - Freeman, T
AU  - Freeman T
FAU - Wooding, P
AU  - Wooding P
FAU - Miazek, A
AU  - Miazek A
FAU - Mattei, M G
AU  - Mattei MG
FAU - Malissen, M
AU  - Malissen M
FAU - Jordan, B R
AU  - Jordan BR
FAU - Malissen, B
AU  - Malissen B
FAU - Carrier, A
AU  - Carrier A
FAU - Naquet, P
AU  - Naquet P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Eur J Immunol
JT  - European journal of immunology
JID - 1273201
RN  - 0 (CC chemokine receptor 9)
RN  - 0 (Ccl25 protein, mouse)
RN  - 0 (Chemokines, CC)
RN  - 0 (DNA, Complementary)
RN  - 0 (Receptors, CCR)
RN  - 0 (Receptors, Chemokine)
SB  - IM
MH  - Animals
MH  - Chemokines, CC/*analysis/genetics
MH  - DNA, Complementary/analysis
MH  - Epithelial Cells/chemistry
MH  - Intestinal Mucosa/*chemistry/immunology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Receptors, CCR
MH  - Receptors, Chemokine/*analysis/genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - T-Lymphocytes/*chemistry
MH  - Thymus Gland/*chemistry
EDAT- 1999/12/22 00:00
MHDA- 1999/12/22 00:01
CRDT- 1999/12/22 00:00
PHST- 1999/12/22 00:00 [pubmed]
PHST- 1999/12/22 00:01 [medline]
PHST- 1999/12/22 00:00 [entrez]
AID - 10.1002/(SICI)1521-4141(200001)30:01<262::AID-IMMU262>3.0.CO;2-M [pii]
AID - 10.1002/1521-4141(200001)30:1<262::AID-IMMU262>3.0.CO;2-0 [doi]
PST - ppublish
SO  - Eur J Immunol. 2000 Jan;30(1):262-71. doi:
      10.1002/1521-4141(200001)30:1<262::AID-IMMU262>3.0.CO;2-0.