PMID- 10602004
OWN - NLM
STAT- MEDLINE
DCOM- 20000104
LR  - 20180420
IS  - 0014-2980 (Print)
IS  - 0014-2980 (Linking)
VI  - 29
IP  - 12
DP  - 1999 Dec
TI  - Biochemical and functional analysis of mice deficient in expression of the
      CD45-associated phosphoprotein LPAP.
PG  - 3956-61
AB  - The role of the CD45-associated phosphoprotein (LPAP / CD45-AP) during an immune 
      response remains unclear. To understand better the function of LPAP we generated 
      LPAP-deficient mice by disrupting exon 2 of the LPAP gene. LPAP-null mice were
      healthy and did not show gross abnormalities compared to their wild-type
      littermates. However, immunofluorescence analysis of T and B lymphocytes revealed
      a reduced expression of CD45, which did not affect a particular subpopulation. In
      contrast to a recent report (Matsuda et al., J. Exp. Med. 1998. 187: 1863 - 1870)
      we neither observed significant alterations of the assembly of the CD45 /
      lck-complex nor of polyclonal T-cell responses. However, lymphnodes from
      LPAP-null mice showed increased cellularity, which could indicate that expression
      of LPAP might be required to prevent expansion of lymphocytes in particular
      lymphatic organs rather than potentiating immune responses.
FAU - Ding, I
AU  - Ding I
AD  - Immunomodulation Laboratory of the Institute for Immunology University of
      Heidelberg, Heidelberg, Germany.
FAU - Bruyns, E
AU  - Bruyns E
FAU - Li, P
AU  - Li P
FAU - Magada, D
AU  - Magada D
FAU - Paskind, M
AU  - Paskind M
FAU - Rodman, L
AU  - Rodman L
FAU - Seshadri, T
AU  - Seshadri T
FAU - Alexander, D
AU  - Alexander D
FAU - Giese, T
AU  - Giese T
FAU - Schraven, B
AU  - Schraven B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Eur J Immunol
JT  - European journal of immunology
JID - 1273201
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Phosphoproteins)
RN  - 0 (Ptprcap protein, mouse)
RN  - EC 3.1.3.48 (Leukocyte Common Antigens)
SB  - IM
MH  - Animals
MH  - Gene Expression Regulation/*immunology
MH  - Intracellular Signaling Peptides and Proteins
MH  - Leukocyte Common Antigens/genetics/*immunology
MH  - Lymphocyte Activation/genetics/immunology
MH  - Membrane Proteins
MH  - Mice
MH  - Mice, Knockout
MH  - Phosphoproteins/*genetics/*immunology
MH  - T-Lymphocytes/*immunology
EDAT- 1999/12/22 00:00
MHDA- 1999/12/22 00:01
CRDT- 1999/12/22 00:00
PHST- 1999/12/22 00:00 [pubmed]
PHST- 1999/12/22 00:01 [medline]
PHST- 1999/12/22 00:00 [entrez]
AID - 10.1002/(SICI)1521-4141(199912)29:12<3956::AID-IMMU3956>3.0.CO;2-G [doi]
PST - ppublish
SO  - Eur J Immunol. 1999 Dec;29(12):3956-61. doi:
      10.1002/(SICI)1521-4141(199912)29:12<3956::AID-IMMU3956>3.0.CO;2-G.