PMID- 10601732
OWN - NLM
STAT- MEDLINE
DCOM- 20000210
LR  - 20191103
IS  - 0945-053X (Print)
IS  - 0945-053X (Linking)
VI  - 18
IP  - 5
DP  - 1999 Oct
TI  - The human CILP gene: exon/intron organization and chromosomal mapping.
PG  - 445-54
AB  - The human cDNA for cartilage intermediate layer protein (CILP) codes for a larger
      precursor protein that consists of CILP and a homologue to porcine Nucleotide
      pyrophosphohydrolase (NTPPHase) [Lorenzo et al. 1998a. J. Biol. Chem. 273,
      23469-23475]. The human gene has now been isolated and characterized. Southern
      blot analysis indicated a single copy of the CILP gene in the human genome. The
      gene spans approximately 15.3 kbp of genomic DNA, and is organized in nine exons.
      The 5' flanking region contains a putative promoter region with a TATA-like box
      localized from -29 to -23 bp upstream of the transcription start site. Analysis
      of the putative promoter region revealed potentially cis-regulatory eukaryotic
      elements such as GATA-1, MyoD, MZF1, and CdxA. The protein coding region begins
      in exon 2 with the putative signal peptide. CILP is encoded from exon 3 to exon
      9. In addition, exon 9 also codes for the entire NTPPHase homologue and contains 
      the 3' untranslated region of the gene. All the introns follow the 'gt-ag' rule, 
      except the last intron, intron 8, that belongs to the minor class of pre-mRNA
      introns that contain 'at-ac' at their 5' and 3' ends, respectively. The CILP gene
      was mapped to human chromosome 15q22.
FAU - Lorenzo, P
AU  - Lorenzo P
AD  - Department of Cell and Molecular Biology, Section for Connective Tissue Biology, 
      University of Lund, Sweden.
FAU - Aman, P
AU  - Aman P
FAU - Sommarin, Y
AU  - Sommarin Y
FAU - Heinegard, D
AU  - Heinegard D
LA  - eng
SI  - GENBANK/AF035447
SI  - GENBANK/AF035448
SI  - GENBANK/AF035449
SI  - GENBANK/AF035451
SI  - GENBANK/AF035453
SI  - GENBANK/AF035455
SI  - GENBANK/AH008465
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Matrix Biol
JT  - Matrix biology : journal of the International Society for Matrix Biology
JID - 9432592
RN  - 0 (DNA Primers)
RN  - 0 (DNA, Complementary)
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (Glycoproteins)
RN  - EC 3.6.1.- (CILP protein, human)
RN  - EC 3.6.1.- (Pyrophosphatases)
SB  - IM
MH  - Base Sequence
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 15/genetics
MH  - Cloning, Molecular
MH  - DNA Primers/genetics
MH  - DNA, Complementary/genetics
MH  - Exons
MH  - Extracellular Matrix Proteins/*genetics
MH  - Glycoproteins/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Introns
MH  - Molecular Sequence Data
MH  - Promoter Regions, Genetic
MH  - *Pyrophosphatases
EDAT- 1999/12/22 00:00
MHDA- 1999/12/22 00:01
CRDT- 1999/12/22 00:00
PHST- 1999/12/22 00:00 [pubmed]
PHST- 1999/12/22 00:01 [medline]
PHST- 1999/12/22 00:00 [entrez]
AID - S0945-053X(99)00035-9 [pii]
AID - 10.1016/s0945-053x(99)00035-9 [doi]
PST - ppublish
SO  - Matrix Biol. 1999 Oct;18(5):445-54. doi: 10.1016/s0945-053x(99)00035-9.