PMID- 10601645
OWN - NLM
STAT- MEDLINE
DCOM- 20000203
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 463
IP  - 1-2
DP  - 1999 Dec 10
TI  - A novel glycosyltransferase with a polyglutamine repeat; a new candidate for
      GD1alpha synthase (ST6GalNAc V)(1).
PG  - 92-6
AB  - The fifth type GalNAcalpha2,6-sialyltransferase (mST6GalNAc V) was cloned from a 
      mouse brain cDNA library. mST6GalNAc V exhibited type II transmembrane topology
      containing a polyglutamine repeat, which showed 42.6% and 44.8% identity to mouse
      ST6GalNAc III and IV, respectively. Northern blot analysis revealed that the
      mST6GalNAc V gene was specifically expressed in forebrain and cerebellum.
      mST6GalNAc V exhibited GD1alpha synthetic activity from GM1b the same as
      mST6GalNAc III and IV. The activity ratio of GM1b toward fetuin and the
      expression pattern were completely different among the three ST6GalNAcs.
      Interestingly, the polyglutamine repeat number was different from that of inbred 
      mice. We report the first glycosyltransferase with a polymorphic polyglutamine
      repeat.
FAU - Ikehara, Y
AU  - Ikehara Y
AD  - Division of Pathology, Aichi Cancer Center Research Institute, Chikusa-ku,
      Nagoya, Japan. yikehara@aichi-cc.pref.aichi.jp
FAU - Shimizu, N
AU  - Shimizu N
FAU - Kono, M
AU  - Kono M
FAU - Nishihara, S
AU  - Nishihara S
FAU - Nakanishi, H
AU  - Nakanishi H
FAU - Kitamura, T
AU  - Kitamura T
FAU - Narimatsu, H
AU  - Narimatsu H
FAU - Tsuji, S
AU  - Tsuji S
FAU - Tatematsu, M
AU  - Tatematsu M
LA  - eng
SI  - GENBANK/AB028840
PT  - Journal Article
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (DNA, Complementary)
RN  - 0 (Peptides)
RN  - 26700-71-0 (polyglutamine)
RN  - 63231-63-0 (RNA)
RN  - EC 2.4.99.- (Sialyltransferases)
RN  - EC 2.4.99.- (brain-specific GD1alpha synthase, ST6GalNAc V)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Blotting, Northern
MH  - Cloning, Molecular
MH  - DNA, Complementary/metabolism
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - Peptides/*genetics
MH  - Phylogeny
MH  - Plasmids
MH  - Polymorphism, Genetic
MH  - RNA/metabolism
MH  - Sialyltransferases/*genetics/isolation & purification/*metabolism
MH  - Substrate Specificity
MH  - Tissue Distribution
MH  - Trinucleotide Repeats
EDAT- 1999/12/22 00:00
MHDA- 1999/12/22 00:01
CRDT- 1999/12/22 00:00
PHST- 1999/12/22 00:00 [pubmed]
PHST- 1999/12/22 00:01 [medline]
PHST- 1999/12/22 00:00 [entrez]
AID - S0014579399016051 [pii]
AID - 10.1016/s0014-5793(99)01605-1 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Dec 10;463(1-2):92-6. doi: 10.1016/s0014-5793(99)01605-1.