PMID- 10601637
OWN - NLM
STAT- MEDLINE
DCOM- 20000203
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 463
IP  - 1-2
DP  - 1999 Dec 10
TI  - Inhibitory effect of pax4 on the human insulin and islet amyloid polypeptide
      (IAPP) promoters.
PG  - 53-7
AB  - Pax4 is a paired-box transcription factor that plays an important role in the
      development of pancreatic beta-cells. Two Pax4 cDNAs were isolated from a rat
      insulinoma library. One contained the full-length sequence of Pax4. The other,
      termed Pax4c, was identical to Pax4 but lacked the sequences encoding 117 amino
      acids at the COOH-terminus. Pax4 was found to inhibit the human insulin promoter 
      through a sequence element, the C2 box, located at -253 to -244, and the islet
      amyloid polypeptide promoter through a sequence element located downstream of
      -138. The inhibitory activity of Pax4 was mapped to separate regions of the
      protein between amino acids 2-230 and 231-349.
FAU - Campbell, S C
AU  - Campbell SC
AD  - Department of Molecular and Cell Biology, University of Aberdeen, Institute of
      Medical Sciences, Foresterhill, Aberdeen, UK.
FAU - Cragg, H
AU  - Cragg H
FAU - Elrick, L J
AU  - Elrick LJ
FAU - Macfarlane, W M
AU  - Macfarlane WM
FAU - Shennan, K I
AU  - Shennan KI
FAU - Docherty, K
AU  - Docherty K
LA  - eng
SI  - GENBANK/AF198155
SI  - GENBANK/AF198156
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Amyloid)
RN  - 0 (DNA, Complementary)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Insulin Antagonists)
RN  - 0 (Islet Amyloid Polypeptide)
RN  - 0 (PAX4 protein, human)
RN  - 0 (Paired Box Transcription Factors)
RN  - 0 (Pax4 protein, mouse)
RN  - 0 (Pax4 protein, rat)
RN  - 0 (Protein Isoforms)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Amyloid/*antagonists & inhibitors/genetics
MH  - Animals
MH  - Cell Line
MH  - Cloning, Molecular
MH  - DNA, Complementary/metabolism
MH  - Gene Library
MH  - Homeodomain Proteins/*genetics/*physiology
MH  - Humans
MH  - *Insulin Antagonists
MH  - Islet Amyloid Polypeptide
MH  - Islets of Langerhans/metabolism
MH  - Mice
MH  - Paired Box Transcription Factors
MH  - Plasmids
MH  - *Promoter Regions, Genetic
MH  - Protein Biosynthesis
MH  - Protein Isoforms
MH  - Rats
MH  - Transcription Factors/*genetics/*physiology
MH  - Transfection
EDAT- 1999/12/22 00:00
MHDA- 1999/12/22 00:01
CRDT- 1999/12/22 00:00
PHST- 1999/12/22 00:00 [pubmed]
PHST- 1999/12/22 00:01 [medline]
PHST- 1999/12/22 00:00 [entrez]
AID - S0014-5793(99)01584-7 [pii]
AID - 10.1016/s0014-5793(99)01584-7 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Dec 10;463(1-2):53-7. doi: 10.1016/s0014-5793(99)01584-7.