PMID- 10601358
OWN - NLM
STAT- MEDLINE
DCOM- 20000128
LR  - 20190508
IS  - 0022-1007 (Print)
IS  - 0022-1007 (Linking)
VI  - 190
IP  - 12
DP  - 1999 Dec 20
TI  - Lineage-specific modulation of interleukin 4 signaling by interferon regulatory
      factor 4.
PG  - 1837-48
AB  - Interleukin (IL)-4 is an immunoregulatory cytokine that exerts distinct
      biological activities on different cell types. Our studies indicate that
      interferon regulatory factor (IRF)-4 is both a target and a modulator of the IL-4
      signaling cascade. IRF-4 expression is strongly upregulated upon costimulation of
      B cells with CD40 and IL-4. Furthermore, we find that IRF-4 can interact with
      signal transducer and activator of transcription (Stat)6 and drive the expression
      of IL-4-inducible genes. The transactivating ability of IRF-4 is blocked by the
      repressor factor BCL-6. Since expression of IRF-4 is mostly confined to lymphoid 
      cells, these data provide a potential mechanism by which IL-4-inducible genes can
      be regulated in a lineage-specific manner.
FAU - Gupta, S
AU  - Gupta S
AD  - Department of Medicine, Columbia University, New York, New York 10032, USA.
FAU - Jiang, M
AU  - Jiang M
FAU - Anthony, A
AU  - Anthony A
FAU - Pernis, A B
AU  - Pernis AB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Interferon Regulatory Factors)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Proto-Oncogene Proteins c-bcl-6)
RN  - 0 (Transcription Factors)
RN  - 0 (interferon regulatory factor-4)
RN  - 207137-56-2 (Interleukin-4)
SB  - IM
MH  - B-Lymphocytes/cytology/*physiology
MH  - Cell Lineage/*physiology
MH  - Cells, Cultured
MH  - DNA-Binding Proteins/*physiology
MH  - Gene Expression Regulation/physiology
MH  - Humans
MH  - Interferon Regulatory Factors
MH  - Interleukin-4/*physiology
MH  - Proto-Oncogene Proteins/*physiology
MH  - Proto-Oncogene Proteins c-bcl-6
MH  - Signal Transduction/physiology
MH  - Transcription Factors/*physiology
PMC - PMC2195723
EDAT- 1999/12/22 00:00
MHDA- 1999/12/22 00:01
CRDT- 1999/12/22 00:00
PHST- 1999/12/22 00:00 [pubmed]
PHST- 1999/12/22 00:01 [medline]
PHST- 1999/12/22 00:00 [entrez]
AID - 10.1084/jem.190.12.1837 [doi]
PST - ppublish
SO  - J Exp Med. 1999 Dec 20;190(12):1837-48. doi: 10.1084/jem.190.12.1837.