PMID- 10601278
OWN - NLM
STAT- MEDLINE
DCOM- 20000113
LR  - 20190508
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 274
IP  - 52
DP  - 1999 Dec 24
TI  - A novel human hepatic organic anion transporting polypeptide (OATP2).
      Identification of a liver-specific human organic anion transporting polypeptide
      and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor
      transporters.
PG  - 37161-8
AB  - A novel human organic transporter, OATP2, has been identified that transports
      taurocholic acid, the adrenal androgen dehydroepiandrosterone sulfate, and
      thyroid hormone, as well as the hydroxymethylglutaryl-CoA reductase inhibitor,
      pravastatin. OATP2 is expressed exclusively in liver in contrast to all other
      known transporter subtypes that are found in both hepatic and nonhepatic tissues.
      OATP2 is considerably diverged from other family members, sharing only 42%
      sequence identity with the four other subtypes. Furthermore, unlike other
      subtypes, OATP2 did not transport digoxin or aldosterone. The rat isoform oatp1
      was also shown to transport pravastatin, whereas other members of the OATP
      family, i.e. rat oatp2, human OATP, and the prostaglandin transporter, did not.
      Cis-inhibition studies indicate that both OATP2 and roatp1 also transport other
      statins including lovastatin, simvastatin, and atorvastatin. In summary, OATP2 is
      a novel organic anion transport protein that has overlapping but not identical
      substrate specificities with each of the other subtypes and, with its
      liver-specific expression, represents a functionally distinct OATP isoform.
      Furthermore, the identification of oatp1 and OATP2 as pravastatin transporters
      suggests that they are responsible for the hepatic uptake of this liver-specific 
      hydroxymethylglutaryl-CoA reductase inhibitor in rat and man.
FAU - Hsiang, B
AU  - Hsiang B
AD  - Bristol-Myers Squibb Co., Pharmaceutical Research Institute, Princeton, New
      Jersey 08543-4000, USA.
FAU - Zhu, Y
AU  - Zhu Y
FAU - Wang, Z
AU  - Wang Z
FAU - Wu, Y
AU  - Wu Y
FAU - Sasseville, V
AU  - Sasseville V
FAU - Yang, W P
AU  - Yang WP
FAU - Kirchgessner, T G
AU  - Kirchgessner TG
LA  - eng
SI  - GENBANK/AF205071
PT  - Journal Article
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (Anion Transport Proteins)
RN  - 0 (Carrier Proteins)
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
RN  - 57B09Q7FJR (Dehydroepiandrosterone Sulfate)
RN  - 5E090O0G3Z (Taurocholic Acid)
RN  - KXO2KT9N0G (Pravastatin)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Anion Transport Proteins
MH  - Base Sequence
MH  - Biological Transport
MH  - Carrier Proteins/*isolation & purification/physiology
MH  - Dehydroepiandrosterone Sulfate/pharmacokinetics
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacokinetics
MH  - Liver/*metabolism
MH  - Molecular Sequence Data
MH  - Pravastatin/pharmacokinetics
MH  - Rats
MH  - Taurocholic Acid/pharmacokinetics
EDAT- 1999/12/22 00:00
MHDA- 1999/12/22 00:01
CRDT- 1999/12/22 00:00
PHST- 1999/12/22 00:00 [pubmed]
PHST- 1999/12/22 00:01 [medline]
PHST- 1999/12/22 00:00 [entrez]
AID - 10.1074/jbc.274.52.37161 [doi]
PST - ppublish
SO  - J Biol Chem. 1999 Dec 24;274(52):37161-8. doi: 10.1074/jbc.274.52.37161.