PMID- 10600506
OWN - NLM
STAT- MEDLINE
DCOM- 20000118
LR  - 20181130
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 266
IP  - 2
DP  - 1999 Dec 20
TI  - Identification and characterization of SorCS, a third member of a novel receptor 
      family.
PG  - 347-51
AB  - A novel receptor, SorCS, was isolated from murine brain. It shows homology to the
      mosaic receptor SorLA and the neurotensin receptor sortilin based on a common
      VPS10 domain which is the hallmark of this new receptor family. In the N-terminus
      of SorCS two putative cleavage sites for the convertase furin mark the beginning 
      of the VPS10 domain, followed by a module of imperfect leucine-rich repeats and a
      transmembrane domain. The short intracellular C-terminus contains consensus
      signals for rapid internalization. The identified putative binding motifs for SH2
      and SH3 domains are unique in the family of VPS10 domain receptors. SorCS is
      predominantly expressed in brain, but also in heart, liver, and kidney. SorCS
      transcripts detected by in situ hybridization in the murine central nervous
      system point to a neuronal expression.
CI  - Copyright 1999 Academic Press.
FAU - Hermey, G
AU  - Hermey G
AD  - Zentrum fur Molekulare Neurobiologie, Universitat Hamburg, Martinistrasse 52,
      Hamburg, 20246, Germany. hermey@zmnh.uni-hamburg.de
FAU - Riedel, I B
AU  - Riedel IB
FAU - Hampe, W
AU  - Hampe W
FAU - Schaller, H C
AU  - Schaller HC
FAU - Hermans-Borgmeyer, I
AU  - Hermans-Borgmeyer I
LA  - eng
SI  - GENBANK/AF137367
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Adaptor Proteins, Vesicular Transport)
RN  - 0 (Fungal Proteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Membrane Transport Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (PEP1 protein, S cerevisiae)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, LDL)
RN  - 0 (Saccharomyces cerevisiae Proteins)
RN  - 0 (SorCS protein, mouse)
RN  - 0 (Sorl1 protein, mouse)
RN  - 0 (Vesicular Transport Proteins)
RN  - Z020Y8WIJ4 (sortilin)
SB  - IM
MH  - Adaptor Proteins, Vesicular Transport
MH  - Amino Acid Sequence
MH  - Animals
MH  - Brain/metabolism
MH  - Cloning, Molecular
MH  - Fungal Proteins/chemistry
MH  - In Situ Hybridization
MH  - Membrane Glycoproteins/chemistry
MH  - *Membrane Transport Proteins
MH  - Mice
MH  - Molecular Sequence Data
MH  - Nerve Tissue Proteins/chemistry/*genetics
MH  - RNA, Messenger/metabolism
MH  - Receptors, Cell Surface/chemistry/*genetics
MH  - *Receptors, LDL
MH  - *Saccharomyces cerevisiae Proteins
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - *Vesicular Transport Proteins
EDAT- 1999/12/22 00:00
MHDA- 1999/12/22 00:01
CRDT- 1999/12/22 00:00
PHST- 1999/12/22 00:00 [pubmed]
PHST- 1999/12/22 00:01 [medline]
PHST- 1999/12/22 00:00 [entrez]
AID - 10.1006/bbrc.1999.1822 [doi]
AID - S0006-291X(99)91822-3 [pii]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1999 Dec 20;266(2):347-51. doi:
      10.1006/bbrc.1999.1822.