PMID- 10600477
OWN - NLM
STAT- MEDLINE
DCOM- 20000111
LR  - 20161124
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 265
IP  - 3
DP  - 1999 Nov 30
TI  - Mice lacking Pin1 develop normally, but are defective in entering cell cycle from
      G(0) arrest.
PG  - 658-63
AB  - The peptidyl prolil cis/trans isomerase Ess1/Pin1 is essential for mitosis
      progression in yeast cells and is hypothesized to perform the same role in
      mammalian cells. To investigate the function of Pin1 in mammalian cells, we
      created mice lacking Pin1. These mice underwent normal development. Although the 
      embryonic Pin1-/- fibroblasts grew normally, they proved significantly deficient 
      in their ability to restart proliferation in response to serum stimulation after 
      G(0) arrest. These results suggest that Pin1 is required for cell cycle
      progression from G(0) arrest as well as mitosis progression in normal mammalian
      cells.
CI  - Copyright 1999 Academic Press.
FAU - Fujimori, F
AU  - Fujimori F
AD  - GeneSurf, Advanced Research Institute for Science and Engineering, Waseda
      University, Tokyo, Japan.
FAU - Takahashi, K
AU  - Takahashi K
FAU - Uchida, C
AU  - Uchida C
FAU - Uchida, T
AU  - Uchida T
LA  - eng
SI  - GENBANK/AB009691
SI  - GENBANK/AB009692
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (DNA Primers)
RN  - 0 (DNA, Complementary)
RN  - 0 (NIMA-Interacting Peptidylprolyl Isomerase)
RN  - EC 5.2.1.8 (Peptidylprolyl Isomerase)
RN  - EC 5.2.1.8 (Pin1 protein, mouse)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Cell Cycle/genetics/*physiology
MH  - Cell Division/genetics/physiology
MH  - Cloning, Molecular
MH  - DNA Primers/genetics
MH  - DNA, Complementary/genetics
MH  - Exons
MH  - Female
MH  - Introns
MH  - Male
MH  - Mice
MH  - Mice, Knockout
MH  - Molecular Sequence Data
MH  - NIMA-Interacting Peptidylprolyl Isomerase
MH  - Peptidylprolyl Isomerase/*deficiency/genetics/physiology
MH  - Phenotype
MH  - Pregnancy
MH  - Resting Phase, Cell Cycle/genetics/physiology
EDAT- 1999/12/22 00:00
MHDA- 1999/12/22 00:01
CRDT- 1999/12/22 00:00
PHST- 1999/12/22 00:00 [pubmed]
PHST- 1999/12/22 00:01 [medline]
PHST- 1999/12/22 00:00 [entrez]
AID - 10.1006/bbrc.1999.1736 [doi]
AID - S0006-291X(99)91736-9 [pii]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1999 Nov 30;265(3):658-63. doi:
      10.1006/bbrc.1999.1736.