PMID- 10600408
OWN - NLM
STAT- MEDLINE
DCOM- 20000217
LR  - 20081121
IS  - 0969-9961 (Print)
IS  - 0969-9961 (Linking)
VI  - 6
IP  - 6
DP  - 1999 Dec
TI  - Pigment epithelium-derived factor delays the death of photoreceptors in mouse
      models of inherited retinal degenerations.
PG  - 523-32
AB  - Pigment epithelium-derived factor (PEDF) is a member of the serine protease
      inhibitor superfamily produced by retinal pigment epithelial cells in the
      developing and adult retina. In vitro, it induces neuronal differentiation of
      retinoblastoma cells and promotes survival of cerebellar granule neurons. The
      pedf gene is closely linked to an autosomal-dominant locus for retinitis
      pigmentosa, suggesting that PEDF could be a survival factor for photoreceptors.
      We have investigated this possibility by injecting PEDF into the eyes of
      homozygous retinal degeneration (rd) and retinal degeneration slow (rds) mice,
      two mutants displaying apoptotic photoreceptor loss. This procedure resulted in a
      transient delay of photoreceptor loss in the rd mouse and a reduction in
      apoptotic photoreceptor profiles in the rds mouse. We conclude that PEDF can act 
      as a survival-promoting factor for photoreceptors in vivo and could potentially
      be useful for the treatment of photoreceptor diseases.
CI  - Copyright 1999 Academic Press.
FAU - Cayouette, M
AU  - Cayouette M
AD  - Faculte de Medecine, Centre de Recherche Universite Laval Robert-Giffard, 2601,
      de la Canardiere, Beauport, Quebec, G1J 2G3, Canada.
FAU - Smith, S B
AU  - Smith SB
FAU - Becerra, S P
AU  - Becerra SP
FAU - Gravel, C
AU  - Gravel C
LA  - eng
GR  - EY09682/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neurobiol Dis
JT  - Neurobiology of disease
JID - 9500169
RN  - 0 (Eye Proteins)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Proteins)
RN  - 0 (Serpins)
RN  - 0 (pigment epithelium-derived factor)
SB  - IM
MH  - Animals
MH  - Apoptosis/*drug effects/physiology
MH  - Cell Survival/drug effects/physiology
MH  - Disease Models, Animal
MH  - *Eye Proteins
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Mice, Mutant Strains
MH  - *Nerve Growth Factors
MH  - Neuroprotective Agents/pharmacology
MH  - Photoreceptor Cells/*drug effects/metabolism
MH  - Proteins/metabolism/*pharmacokinetics
MH  - Retinal Degeneration/*drug therapy/*physiopathology
MH  - Serpins/metabolism/*pharmacokinetics
EDAT- 1999/12/22 09:00
MHDA- 2000/02/19 09:00
CRDT- 1999/12/22 09:00
PHST- 1999/12/22 09:00 [pubmed]
PHST- 2000/02/19 09:00 [medline]
PHST- 1999/12/22 09:00 [entrez]
AID - 10.1006/nbdi.1999.0263 [doi]
AID - S0969-9961(99)90263-2 [pii]
PST - ppublish
SO  - Neurobiol Dis. 1999 Dec;6(6):523-32. doi: 10.1006/nbdi.1999.0263.