PMID- 10597289
OWN - NLM
STAT- MEDLINE
DCOM- 20000106
LR  - 20101118
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 18
IP  - 48
DP  - 1999 Nov 18
TI  - Variable mutation frequencies in coding repeats of TCF-4 and other target genes
      in colon, gastric and endometrial carcinoma showing microsatellite instability.
PG  - 6806-9
AB  - Frameshift mutations in genes containing mononucleotide repeats are often
      observed in cancers exhibiting a high frequency of microsatellite instability
      (MSI-H). Several tumor types, including colorectal, gastric, and endometrial
      carcinomas, display this phenotype in a significant proportion of cases. We
      recently showed in a large series of MSI-H colorectal tumors that approximately
      40% of them exhibited frameshift mutations in an (A)9 tract within the coding
      region of the TCF-4 gene, a crucial member of the APC/beta-catenin/TCF pathway.
      In the present study, we have examined MSI-H cancers from other primary tumor
      sites for mutations in this new target gene. Two of 22 (9%) MSI-H primary gastric
      cancers and none of 23 MSI-H endometrial primary tumors and cell lines were found
      to have a 1 bp deletion in the TCF-4 repeat. In the same series of tumors we also
      looked for frameshift mutations in other coding repeats localized within the TGF 
      beta-RII, BAX, IGFIIR, hMSH3 and hMSH6 genes. Our results suggest that the TCF-4 
      gene, in a similar manner to some of these latter genes, is differentially
      altered in MSI-H tumors from different primary sites.
FAU - Duval, A
AU  - Duval A
AD  - INSERM U434-CEPH, Paris, France.
FAU - Iacopetta, B
AU  - Iacopetta B
FAU - Ranzani, G N
AU  - Ranzani GN
FAU - Lothe, R A
AU  - Lothe RA
FAU - Thomas, G
AU  - Thomas G
FAU - Hamelin, R
AU  - Hamelin R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (DNA, Neoplasm)
RN  - 0 (TCF Transcription Factors)
RN  - 0 (TCF7L2 protein, human)
RN  - 0 (Transcription Factor 7-Like 2 Protein)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Base Sequence
MH  - Colonic Neoplasms/*genetics
MH  - DNA, Neoplasm
MH  - Endometrial Neoplasms/*genetics
MH  - Female
MH  - *Frameshift Mutation
MH  - Humans
MH  - Microsatellite Repeats/*genetics
MH  - Repetitive Sequences, Nucleic Acid
MH  - Stomach Neoplasms/*genetics
MH  - TCF Transcription Factors
MH  - Transcription Factor 7-Like 2 Protein
MH  - Transcription Factors/*genetics
EDAT- 1999/12/22 00:00
MHDA- 1999/12/22 00:01
CRDT- 1999/12/22 00:00
PHST- 1999/12/22 00:00 [pubmed]
PHST- 1999/12/22 00:01 [medline]
PHST- 1999/12/22 00:00 [entrez]
AID - 10.1038/sj.onc.1203287 [doi]
PST - ppublish
SO  - Oncogene. 1999 Nov 18;18(48):6806-9. doi: 10.1038/sj.onc.1203287.