PMID- 10597216
OWN - NLM
STAT- MEDLINE
DCOM- 20000110
LR  - 20141120
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 18
IP  - 46
DP  - 1999 Nov 4
TI  - Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death.
PG  - 6183-90
AB  - Bcl-2 is the best characterized inhibitor of apoptosis, although the molecular
      basis of this action is not fully understood. Using a protein interaction cloning
      procedure, we identified a human gene designated as bis (mapped to chromosome
      10q25) that encoded a novel Bcl-2-interacting protein. Bis protein showed no
      significant homology with Bcl-2 family proteins and had no prominent functional
      motif. Co-immunoprecipitation analysis confirmed that Bis interacted with Bcl-2
      in vivo. DNA transfection experiments indicated that Bis itself exerted only weak
      anti-apoptotic activity, but was synergistic with Bcl-2 in preventing Bax-induced
      and Fas-mediated apoptosis. These results suggest that Bis is a novel modulator
      of cellular anti-apoptotic activity that functions through its interaction with
      Bcl-2.
FAU - Lee, J H
AU  - Lee JH
AD  - Department of Medical Genetics, Osaka University Graduate School of Medicine,
      Japan.
FAU - Takahashi, T
AU  - Takahashi T
FAU - Yasuhara, N
AU  - Yasuhara N
FAU - Inazawa, J
AU  - Inazawa J
FAU - Kamada, S
AU  - Kamada S
FAU - Tsujimoto, Y
AU  - Tsujimoto Y
LA  - eng
SI  - GENBANK/AF127139
SI  - GENBANK/AF130471
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (BAG3 protein, human)
RN  - 0 (Bag3 protein, mouse)
RN  - 0 (Carrier Proteins)
RN  - 0 (DNA, Complementary)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Amino Acid Sequence
MH  - Animals
MH  - Apoptosis/*physiology
MH  - Apoptosis Regulatory Proteins
MH  - B-Lymphocytes/chemistry
MH  - Binding Sites
MH  - Carrier Proteins/genetics/*isolation & purification/metabolism
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 10/*genetics
MH  - Cloning, Molecular
MH  - DNA, Complementary/genetics
MH  - *Genes
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - Organ Specificity
MH  - Protein Structure, Tertiary
MH  - Proto-Oncogene Proteins c-bcl-2/*physiology
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
EDAT- 1999/12/22 00:00
MHDA- 1999/12/22 00:01
CRDT- 1999/12/22 00:00
PHST- 1999/12/22 00:00 [pubmed]
PHST- 1999/12/22 00:01 [medline]
PHST- 1999/12/22 00:00 [entrez]
AID - 10.1038/sj.onc.1203043 [doi]
PST - ppublish
SO  - Oncogene. 1999 Nov 4;18(46):6183-90. doi: 10.1038/sj.onc.1203043.