PMID- 10594652
OWN - NLM
STAT- MEDLINE
DCOM- 20000210
LR  - 20190815
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 11
IP  - 12
DP  - 1999 Dec
TI  - Doc2alpha is an activity-dependent modulator of excitatory synaptic transmission.
PG  - 4262-8
AB  - Doc2alpha is a synaptic vesicle-associated Ca2 + -binding protein. To study the
      role of Doc2alpha in synaptic transmission and modulation, we generated
      homozygous null Doc2alpha mutant mice. In the CA1 region of hippocampal slices in
      the mutant mice, excitatory synaptic responses evoked with prolonged 5 Hz
      stimulation showed a significantly larger frequency facilitation followed by a
      steeper depression than those in wild-type mice, whereas there was no difference 
      in synaptic transmission at lower frequencies or in paired-pulse facilitation.
      These results suggest that Doc2alpha regulates synaptic transmission when high
      Ca2 + concentrations in the presynaptic terminal are sustained. Furthermore, the 
      mutant mice showed impairment in long-term potentiation and passive avoidance
      task. Thus, Doc2alpha may regulate transmitter release during repetitive synaptic
      activation, thereby contributing to memory formation.
FAU - Sakaguchi, G
AU  - Sakaguchi G
AD  - Shionogi Institute for Medical Science, Settsu, Japan.
FAU - Manabe, T
AU  - Manabe T
FAU - Kobayashi, K
AU  - Kobayashi K
FAU - Orita, S
AU  - Orita S
FAU - Sasaki, T
AU  - Sasaki T
FAU - Naito, A
AU  - Naito A
FAU - Maeda, M
AU  - Maeda M
FAU - Igarashi, H
AU  - Igarashi H
FAU - Katsuura, G
AU  - Katsuura G
FAU - Nishioka, H
AU  - Nishioka H
FAU - Mizoguchi, A
AU  - Mizoguchi A
FAU - Itohara, S
AU  - Itohara S
FAU - Takahashi, T
AU  - Takahashi T
FAU - Takai, Y
AU  - Takai Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Doc2a protein, mouse)
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Protein Isoforms)
RN  - 0 (Receptors, Metabotropic Glutamate)
RN  - 0TQU7668EI (Cycloleucine)
RN  - 111900-32-4 (1-amino-1,3-dicarboxycyclopentane)
RN  - 6OTE87SCCW (6-Cyano-7-nitroquinoxaline-2,3-dione)
SB  - IM
MH  - 6-Cyano-7-nitroquinoxaline-2,3-dione/pharmacology
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Calcium-Binding Proteins/genetics/*pharmacology/*physiology
MH  - Cells, Cultured
MH  - Cycloleucine/analogs & derivatives/pharmacology
MH  - Electric Stimulation
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Excitatory Postsynaptic Potentials/drug effects
MH  - Gene Targeting
MH  - Hippocampus/cytology/drug effects
MH  - Long-Term Potentiation/drug effects/genetics
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Neurologic Mutants
MH  - Mutagenesis, Site-Directed
MH  - Nerve Tissue Proteins/genetics/*pharmacology/*physiology
MH  - Neuronal Plasticity/drug effects/genetics
MH  - Neuroprotective Agents/pharmacology
MH  - Protein Isoforms/genetics/physiology
MH  - Receptors, Metabotropic Glutamate/agonists
MH  - Synapses/drug effects/physiology
MH  - Synaptic Transmission/*drug effects/*physiology
EDAT- 1999/12/14 00:00
MHDA- 1999/12/14 00:01
CRDT- 1999/12/14 00:00
PHST- 1999/12/14 00:00 [pubmed]
PHST- 1999/12/14 00:01 [medline]
PHST- 1999/12/14 00:00 [entrez]
AID - ejn855 [pii]
AID - 10.1046/j.1460-9568.1999.00855.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 1999 Dec;11(12):4262-8. doi: 10.1046/j.1460-9568.1999.00855.x.