PMID- 10594173
OWN - NLM
STAT- MEDLINE
DCOM- 20000106
LR  - 20190905
IS  - 0022-2844 (Print)
IS  - 0022-2844 (Linking)
VI  - 49
IP  - 6
DP  - 1999 Dec
TI  - Rapid evolution of the ribonuclease A superfamily: adaptive expansion of
      independent gene clusters in rats and mice.
PG  - 721-8
AB  - The two eosinophil ribonucleases, eosinophil-derived neurotoxin (EDN/RNase 2) and
      eosinophil cationic protein (ECP/RNase 3), are among the most rapidly evolving
      coding sequences known among primates. The eight mouse genes identified as
      orthologs of EDN and ECP form a highly divergent, species-limited cluster. We
      present here the rat ribonuclease cluster, a group of eight distinct ribonuclease
      A superfamily genes that are more closely related to one another than they are to
      their murine counterparts. The existence of independent gene clusters suggests
      that numerous duplications and diversification events have occurred at these loci
      recently, sometime after the divergence of these two rodent species (
      approximately 10-15 million years ago). Nonsynonymous substitutions per site
      (d(N)) calculated for the 64 mouse/rat gene pairs indicate that these
      ribonucleases are incorporating nonsilent mutations at accelerated rates, and
      comparisons of nonsynonymous to synonymous substitution (d(N) / d(S)) suggest
      that diversity in the mouse ribonuclease cluster is promoted by positive
      (Darwinian) selection. Although the pressures promoting similar but clearly
      independent styles of rapid diversification among these primate and rodent genes 
      remain uncertain, our recent findings regarding the function of human EDN suggest
      a role for these ribonucleases in antiviral host defense.
FAU - Singhania, N A
AU  - Singhania NA
AD  - Laboratory of Host Defenses, National Institute of Allergy and Infectious
      Diseases, National Institutes of Health, Building 10 Bethesda, MD 20892, USA.
FAU - Dyer, K D
AU  - Dyer KD
FAU - Zhang, J
AU  - Zhang J
FAU - Deming, M S
AU  - Deming MS
FAU - Bonville, C A
AU  - Bonville CA
FAU - Domachowske, J B
AU  - Domachowske JB
FAU - Rosenberg, H F
AU  - Rosenberg HF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - J Mol Evol
JT  - Journal of molecular evolution
JID - 0360051
RN  - 0 (RNA, Messenger)
RN  - EC 3.1.27.5 (Ribonuclease, Pancreatic)
SB  - IM
MH  - Amino Acid Motifs
MH  - Amino Acid Sequence
MH  - Amino Acid Substitution
MH  - Animals
MH  - Conserved Sequence/genetics
MH  - *Evolution, Molecular
MH  - Genes, Duplicate/genetics
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - Multigene Family/*genetics
MH  - Phylogeny
MH  - RNA, Messenger/analysis/genetics
MH  - Rats
MH  - Ribonuclease, Pancreatic/chemistry/*genetics/*metabolism
MH  - Selection, Genetic
MH  - Sequence Alignment
MH  - Time Factors
EDAT- 1999/12/14 00:00
MHDA- 1999/12/14 00:01
CRDT- 1999/12/14 00:00
PHST- 1999/12/14 00:00 [pubmed]
PHST- 1999/12/14 00:01 [medline]
PHST- 1999/12/14 00:00 [entrez]
AID - JME1944 [pii]
AID - 10.1007/pl00006594 [doi]
PST - ppublish
SO  - J Mol Evol. 1999 Dec;49(6):721-8. doi: 10.1007/pl00006594.