PMID- 10593569
OWN - NLM
STAT- MEDLINE
DCOM- 20000111
LR  - 20190921
IS  - 0891-6934 (Print)
IS  - 0891-6934 (Linking)
VI  - 31
IP  - 1
DP  - 1999
TI  - Chromosomal localization and complete genomic sequence of the murine autoimmune
      regulator gene (Aire).
PG  - 47-53
AB  - We have recently cloned the murine autoimmune regulator (Aire) gene, the
      homologue of human AIRE responsible for the autoimmune polyglandular syndrome
      type 1 (APS1) or autoimmune polyendocrinopathy candidiasis ectodermal dystrophy
      (APECED). Here, we report the genomic sequence (18,413 bp) for the entire Aire
      gene and its 5' flanking region, which contains putative regulatory sequences.
      Comparison of the genomic and cDNA sequences indicates that the Aire gene is
      composed of 14 exons and the coding sequence shares high similarities between
      mouse and human. The sizes of the homologous introns in the two species are
      conserved; however, the introns do not share significant sequence homologies
      except the sequences near the splice donor and acceptor sites. Sequence analyses 
      of the 5' regulatory region and the complete coding region in three mouse strains
      (B6, NOD and SJL) did not reveal any sequence variation, suggesting sequence
      conservation between different inbred mouse strains. Using one of the six
      microsatellite markers identified by genomic sequencing and a B6 x Cast backcross
      mapping panel, we mapped the mouse Aire gene to chromosome 10, a syntenic region 
      containing the Cdl18 and Pfkl genes on human chromosome 21q22.
FAU - Shi, J D
AU  - Shi JD
AD  - Department of Pathology, Immunology and Laboratory Medicine and Center for
      Mammualian Genetics, College of Medicine, University of Florida, Gainesville
      32610-0275, USA.
FAU - Wang, C Y
AU  - Wang CY
FAU - Marron, M P
AU  - Marron MP
FAU - Ruan, Q G
AU  - Ruan QG
FAU - Huang, Y Q
AU  - Huang YQ
FAU - Detter, J C
AU  - Detter JC
FAU - She, J X
AU  - She JX
LA  - eng
SI  - GENBANK/AF079536
SI  - GENBANK/AF105002
SI  - GENBANK/AF128769
SI  - GENBANK/AF128770
SI  - GENBANK/AF128771
SI  - GENBANK/AF128772
SI  - GENBANK/AF128773
PT  - Journal Article
PL  - England
TA  - Autoimmunity
JT  - Autoimmunity
JID - 8900070
RN  - 0 (APECED protein)
RN  - 0 (Transcription Factors)
RN  - 63231-63-0 (RNA)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - *Chromosome Mapping
MH  - Humans
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred NOD
MH  - Microsatellite Repeats/genetics
MH  - Molecular Sequence Data
MH  - Polyendocrinopathies, Autoimmune/genetics
MH  - RNA/isolation & purification
MH  - *Sequence Analysis, DNA
MH  - Transcription Factors/*genetics
EDAT- 1999/12/11 00:00
MHDA- 1999/12/11 00:01
CRDT- 1999/12/11 00:00
PHST- 1999/12/11 00:00 [pubmed]
PHST- 1999/12/11 00:01 [medline]
PHST- 1999/12/11 00:00 [entrez]
AID - 10.3109/08916939908993859 [doi]
PST - ppublish
SO  - Autoimmunity. 1999;31(1):47-53. doi: 10.3109/08916939908993859.