PMID- 10591637
OWN - NLM
STAT- MEDLINE
DCOM- 19991223
LR  - 20191210
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 286
IP  - 5447
DP  - 1999 Dec 10
TI  - Implication of tubby proteins as transcription factors by structure-based
      functional analysis.
PG  - 2119-25
AB  - Tubby-like proteins (TULPs) are found in a broad range of multicellular
      organisms. In mammals, genetic mutation of tubby or other TULPs can result in one
      or more of three disease phenotypes: obesity (from which the name "tubby" is
      derived), retinal degeneration, and hearing loss. These disease phenotypes
      indicate a vital role for tubby proteins; however, no biochemical function has
      yet been ascribed to any member of this protein family. A structure-directed
      approach was employed to investigate the biological function of these proteins.
      The crystal structure of the core domain from mouse tubby was determined at a
      resolution of 1.9 angstroms. From primarily structural clues, experiments were
      devised, the results of which suggest that TULPs are a unique family of bipartite
      transcription factors.
FAU - Boggon, T J
AU  - Boggon TJ
AD  - Structural Biology Program, Department of Physiology and Biophysics, Ruttenberg
      Cancer Center, Mount Sinai School of Medicine of New York University, New York,
      NY 10029, USA.
FAU - Shan, W S
AU  - Shan WS
FAU - Santagata, S
AU  - Santagata S
FAU - Myers, S C
AU  - Myers SC
FAU - Shapiro, L
AU  - Shapiro L
LA  - eng
SI  - PDB/1C8Z
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Eye Proteins)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Proteins)
RN  - 0 (Recombinant Proteins)
RN  - 0 (TULP1 protein, human)
RN  - 0 (TULP2 protein, human)
RN  - 0 (TULP3 protein, human)
RN  - 0 (Transcription Factors)
RN  - 0 (Tub protein, mouse)
RN  - 0 (Tulp1 protein, mouse)
RN  - 0 (Tulp2 protein, mouse)
RN  - 0 (Tulp3 protein, mouse)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Alternative Splicing
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cell Line
MH  - Cell Nucleus/chemistry
MH  - Crystallography, X-Ray
MH  - DNA/metabolism
MH  - Eye Proteins/*chemistry/genetics/*metabolism
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins
MH  - Models, Molecular
MH  - Molecular Sequence Data
MH  - Protein Conformation
MH  - Protein Structure, Secondary
MH  - Protein Structure, Tertiary
MH  - Proteins/*chemistry/genetics/*metabolism
MH  - Recombinant Proteins/chemistry/metabolism
MH  - Sequence Alignment
MH  - Transcription Factors/*chemistry/genetics/*metabolism
MH  - Transcriptional Activation
EDAT- 1999/12/11 00:00
MHDA- 1999/12/11 00:01
CRDT- 1999/12/11 00:00
PHST- 1999/12/11 00:00 [pubmed]
PHST- 1999/12/11 00:01 [medline]
PHST- 1999/12/11 00:00 [entrez]
AID - 8081 [pii]
AID - 10.1126/science.286.5447.2119 [doi]
PST - ppublish
SO  - Science. 1999 Dec 10;286(5447):2119-25. doi: 10.1126/science.286.5447.2119.