PMID- 10591208
OWN - NLM
STAT- MEDLINE
DCOM- 19991216
LR  - 20061115
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 402
IP  - 6761
DP  - 1999 Dec 2
TI  - The DNA sequence of human chromosome 22.
PG  - 489-95
AB  - Knowledge of the complete genomic DNA sequence of an organism allows a systematic
      approach to defining its genetic components. The genomic sequence provides access
      to the complete structures of all genes, including those without known function, 
      their control elements, and, by inference, the proteins they encode, as well as
      all other biologically important sequences. Furthermore, the sequence is a rich
      and permanent source of information for the design of further biological studies 
      of the organism and for the study of evolution through cross-species sequence
      comparison. The power of this approach has been amply demonstrated by the
      determination of the sequences of a number of microbial and model organisms. The 
      next step is to obtain the complete sequence of the entire human genome. Here we 
      report the sequence of the euchromatic part of human chromosome 22. The sequence 
      obtained consists of 12 contiguous segments spanning 33.4 megabases, contains at 
      least 545 genes and 134 pseudogenes, and provides the first view of the complex
      chromosomal landscapes that will be found in the rest of the genome.
FAU - Dunham, I
AU  - Dunham I
AD  - Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
      id1@sanger.ac.uk
FAU - Shimizu, N
AU  - Shimizu N
FAU - Roe, B A
AU  - Roe BA
FAU - Chissoe, S
AU  - Chissoe S
FAU - Hunt, A R
AU  - Hunt AR
FAU - Collins, J E
AU  - Collins JE
FAU - Bruskiewich, R
AU  - Bruskiewich R
FAU - Beare, D M
AU  - Beare DM
FAU - Clamp, M
AU  - Clamp M
FAU - Smink, L J
AU  - Smink LJ
FAU - Ainscough, R
AU  - Ainscough R
FAU - Almeida, J P
AU  - Almeida JP
FAU - Babbage, A
AU  - Babbage A
FAU - Bagguley, C
AU  - Bagguley C
FAU - Bailey, J
AU  - Bailey J
FAU - Barlow, K
AU  - Barlow K
FAU - Bates, K N
AU  - Bates KN
FAU - Beasley, O
AU  - Beasley O
FAU - Bird, C P
AU  - Bird CP
FAU - Blakey, S
AU  - Blakey S
FAU - Bridgeman, A M
AU  - Bridgeman AM
FAU - Buck, D
AU  - Buck D
FAU - Burgess, J
AU  - Burgess J
FAU - Burrill, W D
AU  - Burrill WD
FAU - O'Brien, K P
AU  - O'Brien KP
AU  - et al.
LA  - eng
SI  - GENBANK/AC006285
SI  - GENBANK/AL023733
SI  - GENBANK/AL049708
SI  - GENBANK/AL049749
SI  - GENBANK/AL049760
SI  - GENBANK/AL050347
SI  - GENBANK/AL078611
SI  - GENBANK/AL096754
SI  - GENBANK/AP000522
SI  - GENBANK/AP000523
SI  - GENBANK/AP000524
SI  - GENBANK/AP000525
SI  - GENBANK/AP000526
SI  - GENBANK/AP000527
SI  - GENBANK/AP000528
SI  - GENBANK/AP000529
SI  - GENBANK/AP000530
SI  - GENBANK/AP000531
SI  - GENBANK/AP000532
SI  - GENBANK/AP000533
SI  - GENBANK/AP000534
SI  - GENBANK/AP000535
SI  - GENBANK/AP000536
SI  - GENBANK/AP000537
SI  - GENBANK/AP000538
SI  - GENBANK/AP000539
SI  - GENBANK/AP000540
SI  - GENBANK/AP000541
SI  - GENBANK/AP000542
SI  - GENBANK/Z75892
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 9007-49-2 (DNA)
SB  - IM
CIN - Nature. 1999 Dec 2;402(6761):447-8. PMID: 10591190
CIN - Nature. 1999 Dec 2;402(6761):448. PMID: 10591191
CIN - Nature. 1999 Dec 2;402(6761):467-8. PMID: 10591200
CIN - Nature. 2000 Jan 6;403(6765):12. PMID: 10638729
EIN - Nature 2000 Apr 20;404(6780):904
MH  - Animals
MH  - Chromosome Mapping/methods
MH  - *Chromosomes, Human, Pair 22
MH  - DNA
MH  - Gene Dosage
MH  - *Human Genome Project
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - Repetitive Sequences, Nucleic Acid
MH  - *Sequence Analysis, DNA
MH  - Species Specificity
EDAT- 1999/12/11 09:00
MHDA- 2000/05/29 09:00
CRDT- 1999/12/11 09:00
PHST- 1999/12/11 09:00 [pubmed]
PHST- 2000/05/29 09:00 [medline]
PHST- 1999/12/11 09:00 [entrez]
AID - 10.1038/990031 [doi]
PST - ppublish
SO  - Nature. 1999 Dec 2;402(6761):489-95. doi: 10.1038/990031.