PMID- 10590394
OWN - NLM
STAT- MEDLINE
DCOM- 20000106
LR  - 20071115
IS  - 0040-3709 (Print)
IS  - 0040-3709 (Linking)
VI  - 60
IP  - 6
DP  - 1999 Dec
TI  - CHARGE Association in newborns: a registry-based study.
PG  - 334-43
AB  - The CHARGE Association is a nonrandom occurrence of congenital malformations that
      has been described in clinical series. Reported patients have been selected on
      the basis of certain prior criteria. In this article, we try to identify a
      congenital malformation pattern corresponding to the CHARGE Association, using
      statistical methods and analyzing 5,260 infants with multiple malformations
      collected from four large registries of congenital malformations. Care was taken 
      to identify a number of confounding characteristics that can influence the
      ascertainment and registration of specific congenital malformations. We have
      identified a cluster of malformations that generally agreed with the current
      clinical definition of the CHARGE Association and have added some further
      malformations (e.g., facial clefts). We demonstrate that others (e.g. ,
      esophageal atresia) are probably not part of the pattern. Heart defects (H in the
      acronym) seems to be less helpful in identifying infants with the association. We
      suggest a method to select infants who probably represent the CHARGE Association 
      for analyses of possible risk factors.
CI  - Copyright 1999 Wiley-Liss, Inc.
FAU - Kallen, K
AU  - Kallen K
AD  - Tornblad Institute, University of Lund, S-223 62 Lund, Sweden.
      Karin.Kallen@anatom.lu.se
FAU - Robert, E
AU  - Robert E
FAU - Mastroiacovo, P
AU  - Mastroiacovo P
FAU - Castilla, E E
AU  - Castilla EE
FAU - Kallen, B
AU  - Kallen B
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Teratology
JT  - Teratology
JID - 0153257
SB  - IM
CIN - Teratology. 1999 Dec;60(6):332-3. PMID: 10590393
MH  - Abnormalities, Multiple/classification/*epidemiology
MH  - Choanal Atresia/epidemiology
MH  - Cohort Studies
MH  - Coloboma/epidemiology
MH  - Congenital Abnormalities/classification/*epidemiology
MH  - Epidemiologic Methods
MH  - Europe/epidemiology
MH  - Eye Abnormalities/epidemiology
MH  - Humans
MH  - Infant, Newborn
MH  - *Registries
EDAT- 1999/12/11 00:00
MHDA- 1999/12/11 00:01
CRDT- 1999/12/11 00:00
PHST- 1999/12/11 00:00 [pubmed]
PHST- 1999/12/11 00:01 [medline]
PHST- 1999/12/11 00:00 [entrez]
AID - 10.1002/(SICI)1096-9926(199912)60:6<334::AID-TERA5>3.0.CO;2-S [pii]
AID - 10.1002/(SICI)1096-9926(199912)60:6<334::AID-TERA5>3.0.CO;2-S [doi]
PST - ppublish
SO  - Teratology. 1999 Dec;60(6):334-43. doi:
      10.1002/(SICI)1096-9926(199912)60:6<334::AID-TERA5>3.0.CO;2-S.