PMID- 10590261
OWN - NLM
STAT- MEDLINE
DCOM- 20000124
LR  - 20201208
IS  - 0953-8178 (Print)
IS  - 0953-8178 (Linking)
VI  - 11
IP  - 12
DP  - 1999 Dec
TI  - Isolation and characterization of a novel HS1 SH3 domain binding protein, HS1BP3.
PG  - 1957-64
AB  - We have isolated a novel gene, HS1BP3, which encodes an HS1 binding protein.
      Analysis of HS1BP3 cDNA indicates several potentially important segments,
      including a PX domain, a leucine zipper, immunoreceptor tyrosine-based inhibitory
      motif-like motifs and proline-rich regions. HS1BP3 associates with HS1 proteins
      in vivo as confirmed by immunoprecipitation in B and T cell lines. HS1BP3
      preferentially associates with the HS1 SH3 domains rather than with other SH3
      molecules, suggesting a role of HS1BP3 as an HS1 signaling mediator.
      Overexpression of mutant HS1BP3 protein in T cell lines results in decreased IL-2
      production. Our data suggest a novel role for HS1BP3 in lymphocyte activation.
FAU - Takemoto, Y
AU  - Takemoto Y
AD  - Institute of Immunology, Syntex-Roche, 2669 Yamazaki, Noda, Chiba 278, Japan.
FAU - Furuta, M
AU  - Furuta M
FAU - Sato, M
AU  - Sato M
FAU - Kubo, M
AU  - Kubo M
FAU - Hashimoto, Y
AU  - Hashimoto Y
LA  - eng
SI  - GENBANK/AJ132192
PT  - Journal Article
PL  - England
TA  - Int Immunol
JT  - International immunology
JID - 8916182
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Blood Proteins)
RN  - 0 (Carrier Proteins)
RN  - 0 (HCLS1 protein, human)
RN  - 0 (Interleukin-2)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Blood Proteins/*metabolism
MH  - Carrier Proteins/chemistry/*isolation & purification/physiology
MH  - Cell Line
MH  - Interleukin-2/biosynthesis
MH  - Lymphocyte Activation
MH  - Mice
MH  - Molecular Sequence Data
MH  - *src Homology Domains
EDAT- 1999/12/11 00:00
MHDA- 1999/12/11 00:01
CRDT- 1999/12/11 00:00
PHST- 1999/12/11 00:00 [pubmed]
PHST- 1999/12/11 00:01 [medline]
PHST- 1999/12/11 00:00 [entrez]
AID - 10.1093/intimm/11.12.1957 [doi]
PST - ppublish
SO  - Int Immunol. 1999 Dec;11(12):1957-64. doi: 10.1093/intimm/11.12.1957.