PMID- 10588713
OWN - NLM
STAT- MEDLINE
DCOM- 20000105
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 96
IP  - 25
DP  - 1999 Dec 7
TI  - Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary
      gland development.
PG  - 14378-82
AB  - Pax6, a highly conserved member of the paired homeodomain transcription factor
      family that plays essential roles in ocular, neural, and pancreatic development
      and effects asymmetric transient dorsal expression during pituitary development, 
      with its expression extinguished before the ventral --> dorsal appearance of
      specific cell types. Analysis of pituitary development in the Small eye and Pax6 
      -/- mouse mutants reveals that the dorsoventral axis of the pituitary gland
      becomes ventralized, with dorsal extension of the transcriptional determinants of
      ventral cell types, particularly PFrk. This ventralization is followed by a
      marked decrease in terminally differentiated dorsal somatotrope and lactotrope
      cell types and a marked increase in the expression of markers of the ventral
      thyrotrope cells and SF-1-expressing cells of gonadotrope lineage. We suggest
      that the transient dorsal expression of Pax6 is essential for establishing a
      sharp boundary between dorsal and ventral cell types, based on the inhibition of 
      Shh ventral signals.
FAU - Kioussi, C
AU  - Kioussi C
AD  - Howard Hughes Medical Institute, University of California San Diego, School,
      Department of Medicine, 9500 Gilman Drive, Cellular and Molecular Medicine Room
      345, La Jolla, CA 92093-0648, USA.
FAU - O'Connell, S
AU  - O'Connell S
FAU - St-Onge, L
AU  - St-Onge L
FAU - Treier, M
AU  - Treier M
FAU - Gleiberman, A S
AU  - Gleiberman AS
FAU - Gruss, P
AU  - Gruss P
FAU - Rosenfeld, M G
AU  - Rosenfeld MG
LA  - eng
GR  - R01 DK018477/DK/NIDDK NIH HHS/United States
GR  - 5RO1 DK 18477/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Eye Proteins)
RN  - 0 (Hedgehog Proteins)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (PAX6 Transcription Factor)
RN  - 0 (Paired Box Transcription Factors)
RN  - 0 (Pax6 protein, mouse)
RN  - 0 (Proteins)
RN  - 0 (Repressor Proteins)
RN  - 0 (Trans-Activators)
RN  - 9002-62-4 (Prolactin)
RN  - 9002-72-6 (Growth Hormone)
SB  - IM
MH  - Animals
MH  - DNA-Binding Proteins/*physiology
MH  - Eye Proteins
MH  - Growth Hormone/analysis
MH  - Hedgehog Proteins
MH  - *Homeodomain Proteins
MH  - Mice
MH  - PAX6 Transcription Factor
MH  - Paired Box Transcription Factors
MH  - Pituitary Gland/cytology/*embryology
MH  - Prolactin/analysis
MH  - Proteins/physiology
MH  - Repressor Proteins
MH  - *Trans-Activators
PMC - PMC24444
EDAT- 1999/12/10 00:00
MHDA- 1999/12/10 00:01
CRDT- 1999/12/10 00:00
PHST- 1999/12/10 00:00 [pubmed]
PHST- 1999/12/10 00:01 [medline]
PHST- 1999/12/10 00:00 [entrez]
AID - 10.1073/pnas.96.25.14378 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14378-82. doi:
      10.1073/pnas.96.25.14378.