PMID- 10587646
OWN - NLM
STAT- MEDLINE
DCOM- 20000908
LR  - 20211203
IS  - 1465-7392 (Print)
IS  - 1465-7392 (Linking)
VI  - 1
IP  - 8
DP  - 1999 Dec
TI  - Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB.
PG  - 500-6
AB  - Organismal size is determined by a tightly regulated mechanism that coordinates 
      cell growth, cell proliferation and cell death. The Drosophila insulin 
      receptor/Chico/Dp110 pathway regulates cell and organismal size. Here we show 
      that genetic manipulation of the phosphoinositide-3-OH-kinase-dependent 
      serine/threonine protein kinase Akt (protein kinase B) during development of the 
      Drosophila imaginal disc affects cell and organ size in an autonomous manner. 
      Ectopic expression of Akt does not affect cell-fate determination, apoptosis or 
      proliferation rates in imaginal discs. Thus, Akt appears to stimulate 
      intracellular pathways that specifically regulate cell and compartment size 
      independently of cell proliferation in vivo.
FAU - Verdu, J
AU  - Verdu J
AD  - Howard Hughes Medical Institute and the Department of Medicine, 415 Curie 
      Boulevard, Clinical Research Building, University of Pennsylvania, Philadelphia, 
      Pennsylvania 19104, USA.
FAU - Buratovich, M A
AU  - Buratovich MA
FAU - Wilder, E L
AU  - Wilder EL
FAU - Birnbaum, M J
AU  - Birnbaum MJ
LA  - eng
GR  - GM55162/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Nat Cell Biol
JT  - Nature cell biology
JID - 100890575
RN  - 0 (Drosophila Proteins)
RN  - 0 (Insulin)
RN  - 0 (Phosphoinositide-3 Kinase Inhibitors)
RN  - 0 (Proto-Oncogene Proteins)
RN  - EC 2.7.10.1 (Receptor, Insulin)
RN  - EC 2.7.11.1 (Akt1 protein, Drosophila)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
SB  - IM
CIN - Nat Cell Biol. 1999 Dec;1(8):E191-3. PMID: 10587651
MH  - Animals
MH  - Apoptosis
MH  - Cell Count
MH  - Cell Differentiation
MH  - Cell Division
MH  - Cell Line
MH  - Cell Lineage
MH  - Cell Size
MH  - Clone Cells/cytology/drug effects/enzymology/metabolism
MH  - Drosophila Proteins
MH  - Drosophila melanogaster/*cytology/*embryology/enzymology/genetics
MH  - Enzyme Activation/drug effects
MH  - Eye/cytology/embryology/enzymology/metabolism
MH  - Flow Cytometry
MH  - Insulin/pharmacology
MH  - Kinetics
MH  - Phenotype
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - Phosphoinositide-3 Kinase Inhibitors
MH  - *Protein Serine-Threonine Kinases
MH  - Proto-Oncogene Proteins/genetics/*metabolism
MH  - Proto-Oncogene Proteins c-akt
MH  - Receptor, Insulin/metabolism
MH  - Transformation, Genetic
MH  - Wings, Animal/cytology/embryology/enzymology/metabolism
EDAT- 1999/12/10 09:00
MHDA- 2000/09/19 11:01
CRDT- 1999/12/10 09:00
PHST- 1999/12/10 09:00 [pubmed]
PHST- 2000/09/19 11:01 [medline]
PHST- 1999/12/10 09:00 [entrez]
AID - 10.1038/70293 [doi]
PST - ppublish
SO  - Nat Cell Biol. 1999 Dec;1(8):500-6. doi: 10.1038/70293.