PMID- 10587582
OWN - NLM
STAT- MEDLINE
DCOM- 20000229
LR  - 20190513
IS  - 0964-6906 (Print)
IS  - 0964-6906 (Linking)
VI  - 9
IP  - 1
DP  - 2000 Jan 1
TI  - Significant evidence for linkage of febrile seizures to chromosome 5q14-q15.
PG  - 87-91
AB  - Febrile seizures (FSs) represent the most common form of childhood seizure. In
      the Japanese population, the incidence rate is as high as 7%. It has been
      recognized that there is a significant genetic component for susceptibility to
      this type of seizure. Two putative FS loci, FEB1 (chromosome 8q13-q21) and FEB2
      (chromosome 19p), have been mapped. Furthermore, a mutation in the voltage-gated 
      sodium (Na(+))-channel beta1 subunit gene ( SCN1B ) at chromosome 19q13.1 was
      identified in a family with a clinical subset, termed generalized epilepsy with
      febrile seizures plus (GEFS(+)). These loci are linked to some large families. In
      this study, we conducted a genome-wide linkage search for FS in one large family 
      with subsequent linkage confirmation in 39 nuclear families. Significant linkage 
      was found at D5S644 by multipoint non-parametric analysis using GENEHUNTER ( P = 
      5.4 x 10(-6)). Estimated lambda(s)at D5S644 was 2.5 according to maximum
      likelihood analysis. Significant linkage disequilibria with FS were observed at
      the markers D5S644, D5S652 and D5S2079 in 47 families by transmission
      disequilibrium tests. These findings indicate that there is a gene on chromosome 
      5q14-q15 that confers susceptibility to FSs and we call this gene FEB4.
FAU - Nakayama, J
AU  - Nakayama J
AD  - Department of Medical Genetics, Institute of Basic Medical Sciences, Institute of
      Clinical Medicine, University of Tsukuba, Ibaraki, Japan.
FAU - Hamano, K
AU  - Hamano K
FAU - Iwasaki, N
AU  - Iwasaki N
FAU - Nakahara, S
AU  - Nakahara S
FAU - Horigome, Y
AU  - Horigome Y
FAU - Saitoh, H
AU  - Saitoh H
FAU - Aoki, T
AU  - Aoki T
FAU - Maki, T
AU  - Maki T
FAU - Kikuchi, M
AU  - Kikuchi M
FAU - Migita, T
AU  - Migita T
FAU - Ohto, T
AU  - Ohto T
FAU - Yokouchi, Y
AU  - Yokouchi Y
FAU - Tanaka, R
AU  - Tanaka R
FAU - Hasegawa, M
AU  - Hasegawa M
FAU - Matsui, A
AU  - Matsui A
FAU - Hamaguchi, H
AU  - Hamaguchi H
FAU - Arinami, T
AU  - Arinami T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Hum Mol Genet
JT  - Human molecular genetics
JID - 9208958
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Child, Preschool
MH  - *Chromosomes, Human, Pair 5
MH  - Female
MH  - Genetic Heterogeneity
MH  - *Genetic Linkage
MH  - Genetic Markers
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Models, Genetic
MH  - Pedigree
MH  - Seizures, Febrile/*genetics
MH  - Software
EDAT- 1999/12/10 09:00
MHDA- 2000/03/04 09:00
CRDT- 1999/12/10 09:00
PHST- 1999/12/10 09:00 [pubmed]
PHST- 2000/03/04 09:00 [medline]
PHST- 1999/12/10 09:00 [entrez]
AID - ddd017 [pii]
AID - 10.1093/hmg/9.1.87 [doi]
PST - ppublish
SO  - Hum Mol Genet. 2000 Jan 1;9(1):87-91. doi: 10.1093/hmg/9.1.87.