PMID- 10587367
OWN - NLM
STAT- MEDLINE
DCOM- 20000112
LR  - 20190513
IS  - 1360-9947 (Print)
IS  - 1360-9947 (Linking)
VI  - 5
IP  - 12
DP  - 1999 Dec
TI  - Identification, sequence analysis and expression of transcripts encoding a
      putative metalloproteinase, eMDC II, in human and macaque epididymis.
PG  - 1127-34
AB  - The metalloproteinase-like, disintegrin-like, cysteine-rich (MDC) family is a
      large group of sequence-related proteins, first characterized in the male
      reproductive tract, but subsequently also identified in non-reproductive tissues.
      Their primary translation products are of approximately 90 kDa and each can be
      divided into distinct domains which show remarkable homology to reprolysins;
      snake venom haemorrhagic components possessing metalloproteinase and/or
      disintegrin domains. Several MDC proteins are abundantly-expressed in the male
      reproductive tract, suggesting functions in fertility. We now describe the
      cloning, sequence determination and characterization of transcripts encoding the 
      human and macaque (Macaca fascicularis) orthologues of a novel member of the MDC 
      family (eMDC II) which is abundantly-expressed in the epididymis. Unlike many MDC
      proteins expressed in the reproductive tract, eMDC II possesses the extended
      'catalytic centre' consensus sequence characteristic of a reprolysin-like
      metalloproteinase. This suggests that eMDC II has proteolytic activity.
FAU - Jury, J A
AU  - Jury JA
AD  - Department of Biochemistry, University of Bristol, School of Medical Sciences,
      Bristol, BS8 1TD, UK.
FAU - Perry, A C
AU  - Perry AC
FAU - Hall, L
AU  - Hall L
LA  - eng
SI  - GENBANK/AJ242014
SI  - GENBANK/AJ242015
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Mol Hum Reprod
JT  - Molecular human reproduction
JID - 9513710
RN  - EC 3.4.24.- (ADAM Proteins)
RN  - EC 3.4.24.- (ADAM28 protein, human)
RN  - EC 3.4.24.- (Metalloendopeptidases)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - ADAM Proteins
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Binding Sites
MH  - Catalytic Domain
MH  - Cloning, Molecular
MH  - Epididymis/*enzymology
MH  - Female
MH  - Gene Expression Profiling
MH  - Humans
MH  - Macaca fascicularis
MH  - Male
MH  - Metalloendopeptidases/*genetics/*metabolism
MH  - Molecular Sequence Data
MH  - Sequence Analysis
MH  - Transcription, Genetic
MH  - Zinc/metabolism
EDAT- 1999/12/10 00:00
MHDA- 1999/12/10 00:01
CRDT- 1999/12/10 00:00
PHST- 1999/12/10 00:00 [pubmed]
PHST- 1999/12/10 00:01 [medline]
PHST- 1999/12/10 00:00 [entrez]
AID - 10.1093/molehr/5.12.1127 [doi]
PST - ppublish
SO  - Mol Hum Reprod. 1999 Dec;5(12):1127-34. doi: 10.1093/molehr/5.12.1127.