PMID- 10587360
OWN - NLM
STAT- MEDLINE
DCOM- 20000113
LR  - 20190508
IS  - 0022-1007 (Print)
IS  - 0022-1007 (Linking)
VI  - 190
IP  - 11
DP  - 1999 Dec 6
TI  - Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune
      manifestations.
PG  - 1697-710
AB  - The cause of many autoimmune and inflammatory diseases is unresolved, although
      dysregulated production of tumor necrosis factor (TNF) family members appears to 
      be important in many cases. BAFF, a new member of the TNF family, binds to B
      cells and costimulates their growth in vitro. Mice transgenic for BAFF have
      vastly increased numbers of mature B and effector T cells, and develop
      autoimmune-like manifestations such as the presence of high levels of rheumatoid 
      factors, circulating immune complexes, anti-DNA autoantibodies, and
      immunoglobulin deposition in the kidneys. This phenotype is reminiscent of
      certain human autoimmune disorders and suggests that dysregulation of BAFF
      expression may be a critical element in the chain of events leading to
      autoimmunity.
FAU - Mackay, F
AU  - Mackay F
AD  - Department of Immunology, Inflammation and Cell Biology, Biogen, Cambridge,
      Massachusetts 02142, USA. fabienne_mackay@biogen.com
FAU - Woodcock, S A
AU  - Woodcock SA
FAU - Lawton, P
AU  - Lawton P
FAU - Ambrose, C
AU  - Ambrose C
FAU - Baetscher, M
AU  - Baetscher M
FAU - Schneider, P
AU  - Schneider P
FAU - Tschopp, J
AU  - Tschopp J
FAU - Browning, J L
AU  - Browning JL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Autoantibodies)
RN  - 0 (B-Cell Activating Factor)
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
RN  - 0 (Immunoglobulins)
RN  - 0 (Membrane Proteins)
RN  - 0 (TNFSF13B protein, human)
RN  - 0 (Tnfsf13b protein, mouse)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9009-79-4 (Rheumatoid Factor)
SB  - IM
MH  - Animals
MH  - Antibodies, Antinuclear/blood
MH  - Autoantibodies/*blood
MH  - Autoimmune Diseases/genetics/*immunology/pathology
MH  - B-Cell Activating Factor
MH  - B-Lymphocytes/*immunology
MH  - Flow Cytometry
MH  - Humans
MH  - Immunoglobulin A/blood
MH  - Immunoglobulin G/blood
MH  - Immunoglobulin M/blood
MH  - Immunoglobulins/metabolism
MH  - Kidney/immunology/pathology
MH  - Kinetics
MH  - Leukocyte Count
MH  - Lung/immunology
MH  - Lymphatic Diseases/genetics/*immunology/pathology
MH  - Membrane Proteins/*genetics/*immunology
MH  - Mice
MH  - Mice, Transgenic
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Rheumatoid Factor/blood
MH  - T-Lymphocytes/immunology
MH  - Tumor Necrosis Factor-alpha/*genetics/*immunology
PMC - PMC2195729
EDAT- 1999/12/10 00:00
MHDA- 1999/12/10 00:01
CRDT- 1999/12/10 00:00
PHST- 1999/12/10 00:00 [pubmed]
PHST- 1999/12/10 00:01 [medline]
PHST- 1999/12/10 00:00 [entrez]
AID - 10.1084/jem.190.11.1697 [doi]
PST - ppublish
SO  - J Exp Med. 1999 Dec 6;190(11):1697-710. doi: 10.1084/jem.190.11.1697.