PMID- 10587356
OWN - NLM
STAT- MEDLINE
DCOM- 20000113
LR  - 20190508
IS  - 0022-1007 (Print)
IS  - 0022-1007 (Linking)
VI  - 190
IP  - 11
DP  - 1999 Dec 6
TI  - RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell
      activation.
PG  - 1657-68
AB  - A novel T cell-specific adaptor protein, RIBP, was identified based on its
      ability to bind Rlk/Txk in a yeast two-hybrid screen of a mouse T cell lymphoma
      library. RIBP was also found to interact with a related member of the Tec family 
      of tyrosine kinases, Itk. Expression of RIBP is restricted to T and natural
      killer cells and is upregulated substantially after T cell activation.
      RIBP-disrupted knockout mice displayed apparently normal T cell development.
      However, proliferation of RIBP-deficient T cells in response to T cell receptor
      (TCR)-mediated activation was significantly impaired. Furthermore, these
      activated T cells were defective in the production of interleukin (IL)-2 and
      interferon gamma, but not IL-4. These data suggest that RIBP plays an important
      role in TCR-mediated signal transduction pathways and that its binding to Itk and
      Rlk/Txk may regulate T cell differentiation.
FAU - Rajagopal, K
AU  - Rajagopal K
AD  - Committee on Immunology, University of Chicago, Chicago, Illinois 60637, USA.
FAU - Sommers, C L
AU  - Sommers CL
FAU - Decker, D C
AU  - Decker DC
FAU - Mitchell, E O
AU  - Mitchell EO
FAU - Korthauer, U
AU  - Korthauer U
FAU - Sperling, A I
AU  - Sperling AI
FAU - Kozak, C A
AU  - Kozak CA
FAU - Love, P E
AU  - Love PE
FAU - Bluestone, J A
AU  - Bluestone JA
LA  - eng
SI  - GENBANK/AF203343
GR  - P01 AI35294-6/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Carrier Proteins)
RN  - 0 (Interleukin-2)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Sh2d2a protein, mouse)
RN  - EC 2.7.1.- (Tec protein-tyrosine kinase)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.2 (emt protein-tyrosine kinase)
SB  - IM
MH  - *Adaptor Proteins, Signal Transducing
MH  - Amino Acid Sequence
MH  - Animals
MH  - Carrier Proteins/*genetics/*metabolism
MH  - Cell Line
MH  - Cells, Cultured
MH  - *Chromosome Mapping
MH  - Cloning, Molecular
MH  - Crosses, Genetic
MH  - Gene Library
MH  - Humans
MH  - Interleukin-2/biosynthesis
MH  - Killer Cells, Natural/*immunology
MH  - *Lymphocyte Activation
MH  - Lymphoma, T-Cell
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Mice, Knockout
MH  - Molecular Sequence Data
MH  - Muridae
MH  - Protein-Tyrosine Kinases/*metabolism
MH  - Recombinant Proteins/metabolism
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - T-Lymphocytes/*immunology
MH  - Transfection
MH  - Tumor Cells, Cultured
PMC - PMC2195727
EDAT- 1999/12/10 00:00
MHDA- 1999/12/10 00:01
CRDT- 1999/12/10 00:00
PHST- 1999/12/10 00:00 [pubmed]
PHST- 1999/12/10 00:01 [medline]
PHST- 1999/12/10 00:00 [entrez]
AID - 10.1084/jem.190.11.1657 [doi]
PST - ppublish
SO  - J Exp Med. 1999 Dec 6;190(11):1657-68. doi: 10.1084/jem.190.11.1657.