PMID- 10585778
OWN - NLM
STAT- MEDLINE
DCOM- 20000204
LR  - 20170922
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 62
IP  - 1
DP  - 1999 Nov 15
TI  - Identification of a novel homolog of the Drosophila staufen protein in the
      chromosome 8q13-q21.1 region.
PG  - 113-8
AB  - We report the identification of a new transcript homologous to the Drosophila
      staufen protein. This transcript, named STAU2 (HGMW-approved gene symbol and
      name), maps to the chromosome 8q13-q21 region. The full-length STAU2 cDNA is 4058
      bp and contains an open reading frame of 479 amino acids. Analysis of the
      predicted protein product indicated the presence of three double-stranded
      RNA-binding domains. Best-fit analysis revealed a 48.5% similarity to the
      Drosophila protein and a 59.9% similarity to the recently described mammalian
      homolog hStau, indicating that at least two different transcripts with homologies
      to the fly protein are present in mammals.
CI  - Copyright 1999 Academic Press.
FAU - Buchner, G
AU  - Buchner G
AD  - Telethon Institute of Genetics and Medicine (TIGEM), San Raffaele Biomedical
      Science Park, Milan, Italy.
FAU - Bassi, M T
AU  - Bassi MT
FAU - Andolfi, G
AU  - Andolfi G
FAU - Ballabio, A
AU  - Ballabio A
FAU - Franco, B
AU  - Franco B
LA  - eng
SI  - GENBANK/AJ244015
SI  - GENBANK/AL078636
SI  - GENBANK/Y19062
GR  - TGM06S01/Telethon/Italy
GR  - TGM97000/Telethon/Italy
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (DNA, Complementary)
RN  - 0 (Drosophila Proteins)
RN  - 0 (RNA-Binding Proteins)
RN  - 139568-71-1 (stau protein, Drosophila)
RN  - 63231-63-0 (RNA)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Binding Sites
MH  - Chromosomes, Human, Pair 8/*genetics
MH  - DNA, Complementary/genetics
MH  - *Drosophila Proteins
MH  - Drosophila melanogaster/*genetics
MH  - Expressed Sequence Tags
MH  - Gene Duplication
MH  - Gene Expression
MH  - *Genes
MH  - Genetic Diseases, Inborn/genetics
MH  - Humans
MH  - Mammals/genetics
MH  - Molecular Sequence Data
MH  - Open Reading Frames
MH  - Protein Structure, Tertiary
MH  - RNA/metabolism
MH  - RNA-Binding Proteins/*genetics
MH  - Sequence Alignment
MH  - Sequence Homology
MH  - Species Specificity
EDAT- 1999/12/10 00:00
MHDA- 1999/12/10 00:01
CRDT- 1999/12/10 00:00
PHST- 1999/12/10 00:00 [pubmed]
PHST- 1999/12/10 00:01 [medline]
PHST- 1999/12/10 00:00 [entrez]
AID - 10.1006/geno.1999.6015 [doi]
AID - S0888-7543(99)96015-9 [pii]
PST - ppublish
SO  - Genomics. 1999 Nov 15;62(1):113-8. doi: 10.1006/geno.1999.6015.