PMID- 10585776
OWN - NLM
STAT- MEDLINE
DCOM- 20000204
LR  - 20061115
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 62
IP  - 1
DP  - 1999 Nov 15
TI  - Characterization of TNFRSF19, a novel member of the tumor necrosis factor
      receptor superfamily.
PG  - 103-7
AB  - By searching the expressed sequence tag database, a novel murine tumor necrosis
      factor receptor designated TNFRSF19 was identified. TNFRSF19 cDNA encodes a
      putative membrane protein of 348 amino acids with one incomplete and two complete
      cysteine-rich motifs within its extracellular region and a large cytoplasmic
      domain. TNFRSF19 mRNA can be detected in most murine tissues examined,
      particularly in brain, reproductive organs, and late developmental stages of
      murine embryo, but not in tissues of the immune system. The cell surface
      expression of the ligand of TNFRSF19 is highly restricted. Of 22 human and murine
      cell lines examined by FACS analysis, only Raji (B cell lymphoma cell line),
      GM847 (fibroblast cell line), 293 (embryonic kidney cell line), and K562 (chronic
      myeloid leukemia) were positive. TNFRSF19 did not bind newly cloned TNF ligands, 
      including TWEAK (HGMW-approved symbol TNFSF12), VEGI/TL1 (HGMW-approved symbol
      TNFSF15), TL6/endokine (HGMW-approved symbol TNFSF18), APRIL (HGMW-approved
      symbol TNFSF13), OPGL (HGMW-approved symbol TNFSF11), LIGHT (HGMW-approved symbol
      TNFSF14), or BAFF/THANK (HGMW-approved symbol TNFSF13B) by enzyme-linked
      immunosorbent assay and FACS analyses. Overexpression of TNFRSF19 transduced
      neither apoptotic signaling nor signals leading to NF-kappaB induction. Taken
      together with the data that the TNFRSF19 extracellular domain-immunoglobulin
      fusion protein did not affect the allogeneic mixed lymphocyte reaction, our data 
      indicate that TNFRSF19 is not involved in the modulation of immune responses.
CI  - Copyright 1999 Academic Press.
FAU - Hu, S
AU  - Hu S
AD  - Mayo Graduate and Medical Schools, Mayo Clinic, Rochester, Minnesota 55905, USA.
FAU - Tamada, K
AU  - Tamada K
FAU - Ni, J
AU  - Ni J
FAU - Vincenz, C
AU  - Vincenz C
FAU - Chen, L
AU  - Chen L
LA  - eng
SI  - GENBANK/AF173166
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (Fetal Proteins)
RN  - 0 (Ligands)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Recombinant Fusion Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Apoptosis
MH  - Cell Line
MH  - Embryonic and Fetal Development/genetics
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Expressed Sequence Tags
MH  - Fetal Proteins/biosynthesis/genetics
MH  - Flow Cytometry
MH  - *Genes
MH  - Humans
MH  - Immunity/genetics
MH  - Ligands
MH  - Lymphocyte Culture Test, Mixed
MH  - Mice/*genetics
MH  - Molecular Sequence Data
MH  - *Multigene Family
MH  - Neoplasm Proteins/biosynthesis/genetics
MH  - Organ Specificity
MH  - Protein Binding
MH  - Protein Structure, Tertiary
MH  - Receptors, Tumor Necrosis Factor/biosynthesis/*genetics/physiology
MH  - Recombinant Fusion Proteins/biosynthesis/genetics
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Signal Transduction
MH  - Transcription, Genetic
MH  - Transfection
MH  - Tumor Cells, Cultured
EDAT- 1999/12/10 00:00
MHDA- 1999/12/10 00:01
CRDT- 1999/12/10 00:00
PHST- 1999/12/10 00:00 [pubmed]
PHST- 1999/12/10 00:01 [medline]
PHST- 1999/12/10 00:00 [entrez]
AID - 10.1006/geno.1999.5979 [doi]
AID - S0888-7543(99)95979-7 [pii]
PST - ppublish
SO  - Genomics. 1999 Nov 15;62(1):103-7. doi: 10.1006/geno.1999.5979.