PMID- 10585775
OWN - NLM
STAT- MEDLINE
DCOM- 20000204
LR  - 20061115
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 62
IP  - 1
DP  - 1999 Nov 15
TI  - Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1)
      gene: cDNA sequence, genomic organization, chromosomal localization, and tissue
      expression.
PG  - 98-102
AB  - Brown adipose and muscle tissues can increase energy expenditure via adaptive
      thermogenesis, thereby protecting against obesity. Mouse peroxisome proliferator 
      activated receptor gamma coactivator 1 (Pgc1) has been reported to enhance the
      expression of uncoupling protein-1, a key mediator of thermogenesis in brown
      adipose tissue (Puigserver et al., 1998, Cell 92, 829-839). We report here the
      characterization of the human PPARGC1 gene. PPARGC1 spans a genomic region of
      approximately 67 kb, is composed of 13 exons, and encodes a 91-kDa protein that
      exhibits 94% amino acid identity with the mouse ortholog. mRNA species,
      transcribed from the TATA-less promoter, are 6.4 and 5.3 kb in length due to
      utilization of two polyadenylation signals. Northern blotting revealed expression
      of both transcripts in heart, skeletal muscle, and kidney and to a lesser extent 
      in liver, brain, and pancreas as well as in the perirenal adipose tissue of a
      pheochromocytoma patient. PPARGC1 was mapped to chromosome 4p15.1, a region that 
      has been associated with basal insulin levels in Pima Indians. Hence, PPARGC1
      expression might influence insulin sensitivity as well as energy expenditure,
      thereby contributing to the development and pathophysiology of human obesity.
CI  - Copyright 1999 Academic Press.
FAU - Esterbauer, H
AU  - Esterbauer H
AD  - Department of Laboratory Medicine, Landeskliniken Salzburg, Salzburg, Austria.
FAU - Oberkofler, H
AU  - Oberkofler H
FAU - Krempler, F
AU  - Krempler F
FAU - Patsch, W
AU  - Patsch W
LA  - eng
SI  - GENBANK/AF106698
SI  - GENBANK/AF108193
SI  - GENBANK/AF108194
SI  - GENBANK/AF108195
SI  - GENBANK/AF108196
SI  - GENBANK/AF108197
SI  - GENBANK/AF108198
SI  - GENBANK/AF108199
SI  - GENBANK/AF108200
SI  - GENBANK/AF108201
SI  - GENBANK/AF108202
SI  - GENBANK/AF108203
SI  - GENBANK/AF108204
SI  - GENBANK/AF108205
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (DNA, Complementary)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transcription Factors)
RN  - 0 (peroxisome-proliferator-activated receptor-gamma coactivator-1)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Binding Sites
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 4/*genetics
MH  - DNA, Complementary/genetics
MH  - Energy Metabolism/*genetics
MH  - Exons/genetics
MH  - Gene Expression Regulation
MH  - *Genes
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Indians, North American/*genetics
MH  - Insulin Resistance/*genetics
MH  - Mice
MH  - Molecular Sequence Data
MH  - Multigene Family
MH  - Organ Specificity
MH  - Polymerase Chain Reaction
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Transcription Factors/biosynthesis/*genetics/metabolism/physiology
EDAT- 1999/12/10 00:00
MHDA- 1999/12/10 00:01
CRDT- 1999/12/10 00:00
PHST- 1999/12/10 00:00 [pubmed]
PHST- 1999/12/10 00:01 [medline]
PHST- 1999/12/10 00:00 [entrez]
AID - 10.1006/geno.1999.5977 [doi]
AID - S0888-7543(99)95977-3 [pii]
PST - ppublish
SO  - Genomics. 1999 Nov 15;62(1):98-102. doi: 10.1006/geno.1999.5977.