PMID- 10585771
OWN - NLM
STAT- MEDLINE
DCOM- 20000204
LR  - 20071115
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 62
IP  - 1
DP  - 1999 Nov 15
TI  - ZNF74, a gene deleted in DiGeorge syndrome, is expressed in human neural
      crest-derived tissues and foregut endoderm epithelia.
PG  - 82-5
AB  - DiGeorge syndrome (DGS) is a developmental disorder associated with large
      hemizygous deletions on chromosome 22q11.2. ZNF74 zinc finger gene is a candidate
      from the commonly deleted region. To address the potential involvement of ZNF74
      in DGS, its human developmental expression pattern has been assessed. In situ
      hybridization on Carnegie Stage 18 embryos revealed that ZNF74 expression is
      limited to specific neural crest-derived tissues and neuroepithelium of the
      spinal cord as well as to foregut endoderm epithelia (esophagus and respiratory
      tract). Interestingly, ZNF74 expression was detected in the wall of the pulmonary
      artery and aorta and in the aortic valve, which are populated by neural
      crest-derived cells. This finding is significant, considering that DGS is
      believed to result from defective neural crest contributions and that outflow
      tract and aorticopulmonary septation defects are typical features of the DGS
      phenotype. Thus, the restricted expression of ZNF74 in structures affected in DGS
      suggests a role for this putative regulator of gene expression in aspects of the 
      DGS phenotype.
CI  - Copyright 1999 Academic Press.
FAU - Ravassard, P
AU  - Ravassard P
AD  - Laboratoire de Genetique Moleculaire de la Neurotransmission et des Processus
      Neurodegeneratifs, CNRS-UMR C9923, Paris, France.
FAU - Cote, F
AU  - Cote F
FAU - Grondin, B
AU  - Grondin B
FAU - Bazinet, M
AU  - Bazinet M
FAU - Mallet, J
AU  - Mallet J
FAU - Aubry, M
AU  - Aubry M
LA  - eng
SI  - GENBANK/X71623
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (Fetal Proteins)
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 0 (RNA-Binding Proteins)
RN  - 0 (ZNF74 protein, human)
SB  - IM
MH  - Aorta/embryology/metabolism
MH  - Aortic Valve/embryology/metabolism
MH  - Cell Lineage
MH  - Chromosomes, Human, Pair 22/*genetics
MH  - DiGeorge Syndrome/*genetics/pathology
MH  - Embryonic and Fetal Development/genetics
MH  - Endoderm/*metabolism
MH  - Epithelial Cells/metabolism
MH  - Fetal Proteins/biosynthesis/*genetics
MH  - *Gene Deletion
MH  - *Gene Expression Regulation, Developmental
MH  - Genes
MH  - Humans
MH  - Kruppel-Like Transcription Factors
MH  - Molecular Sequence Data
MH  - Neural Crest/*metabolism
MH  - Organ Specificity
MH  - Phenotype
MH  - Pulmonary Artery/embryology/metabolism
MH  - RNA-Binding Proteins/biosynthesis/*genetics
MH  - Zinc Fingers/genetics
EDAT- 1999/12/10 00:00
MHDA- 1999/12/10 00:01
CRDT- 1999/12/10 00:00
PHST- 1999/12/10 00:00 [pubmed]
PHST- 1999/12/10 00:01 [medline]
PHST- 1999/12/10 00:00 [entrez]
AID - 10.1006/geno.1999.5982 [doi]
AID - S0888754399959827 [pii]
PST - ppublish
SO  - Genomics. 1999 Nov 15;62(1):82-5. doi: 10.1006/geno.1999.5982.