PMID- 10585766
OWN - NLM
STAT- MEDLINE
DCOM- 20000204
LR  - 20161124
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 62
IP  - 1
DP  - 1999 Nov 15
TI  - Genomic organization, expression, and chromosome location of the human SNAIL gene
      (SNAI1) and a related processed pseudogene (SNAI1P).
PG  - 42-9
AB  - Some of the zinc finger proteins of the snail family are essential in the
      formation of mesoderm during gastrulation and the development of neural crest and
      its derivatives. We have isolated the human SNAIL gene (HGMW-approved symbol
      SNAI1) and describe its genomic organization, having sequenced a region spanning 
      more than 5882 bp. The human SNAIL gene contains three exons. The SNAIL
      transcript is 2. 0 kb and is found in placenta and adult heart, lung, brain,
      liver, and skeletal muscle. It codes for a protein of 264 amino acids and 29.1
      kDa. This protein contains three classic zinc fingers and one atypical zinc
      finger. The human SNAIL protein is 87.5, 58.7, 50.9, 50.7, 55.4, and 31.5%
      identical to mouse Snail, chicken snail-like, zebrafish snail1, zebrafish snail2,
      Xenopus snail, and Drosophila snail proteins, respectively. The zinc finger
      region is 95.5% identical between human and mouse Snail. Because Drosophila snail
      and twist are important regulators during mesoderm development and because human 
      TWIST mutations have been implicated in craniosynostosis, a cohort of 59 patients
      with craniosynostosis syndromes were screened for SNAIL mutations. None were
      found. By somatic cell and radiation hybrid mapping panels, SNAIL was localized
      to human chromosome 20q13.2, between markers D20S886 and D20S109. A
      SNAIL-related, putative processed pseudogene (HGMW-approved symbol SNAI1P) was
      also isolated and maps to human chromosome 2q33-q37.
CI  - Copyright 1999 Academic Press.
FAU - Paznekas, W A
AU  - Paznekas WA
AD  - Department of Medicine, Center for Craniofacial Development and Disorders,
      McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School
      of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287-3914, USA.
FAU - Okajima, K
AU  - Okajima K
FAU - Schertzer, M
AU  - Schertzer M
FAU - Wood, S
AU  - Wood S
FAU - Jabs, E W
AU  - Jabs EW
LA  - eng
SI  - GENBANK/AF153502
SI  - GENBANK/AF155233
SI  - GENBANK/AF177731
GR  - P50 DE11131/DE/NIDCR NIH HHS/United States
GR  - P60 DE13078/DE/NIDCR NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (DNA, Complementary)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Fetal Proteins)
RN  - 0 (SNAI1 protein, human)
RN  - 0 (Snai1 protein, mouse)
RN  - 0 (Snail Family Transcription Factors)
RN  - 0 (Transcription Factors)
RN  - 0 (sna protein, Drosophila)
SB  - IM
MH  - Adult
MH  - Amino Acid Sequence
MH  - Animals
MH  - Chromosomes, Human, Pair 2/*genetics
MH  - Chromosomes, Human, Pair 20/*genetics
MH  - Cohort Studies
MH  - Craniosynostoses/*genetics
MH  - DNA Mutational Analysis
MH  - DNA, Complementary/genetics
MH  - DNA-Binding Proteins/*genetics
MH  - Drosophila melanogaster/genetics
MH  - Embryonic and Fetal Development/genetics
MH  - Exons/genetics
MH  - Expressed Sequence Tags
MH  - Fetal Proteins/genetics
MH  - *Genes
MH  - Humans
MH  - Hybrid Cells
MH  - Male
MH  - Mesoderm/physiology
MH  - Molecular Sequence Data
MH  - Morphogenesis/genetics
MH  - Neural Crest/physiology
MH  - Organ Specificity
MH  - *Pseudogenes
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Snail Family Transcription Factors
MH  - Species Specificity
MH  - Transcription Factors/*genetics
MH  - Vertebrates/genetics
MH  - Zebrafish/genetics
MH  - Zinc Fingers/*genetics
EDAT- 1999/12/10 00:00
MHDA- 1999/12/10 00:01
CRDT- 1999/12/10 00:00
PHST- 1999/12/10 00:00 [pubmed]
PHST- 1999/12/10 00:01 [medline]
PHST- 1999/12/10 00:00 [entrez]
AID - 10.1006/geno.1999.6010 [doi]
AID - S0888-7543(99)96010-X [pii]
PST - ppublish
SO  - Genomics. 1999 Nov 15;62(1):42-9. doi: 10.1006/geno.1999.6010.