PMID- 10585566
OWN - NLM
STAT- MEDLINE
DCOM- 20000228
LR  - 20191210
IS  - 0925-4773 (Print)
IS  - 0925-4773 (Linking)
VI  - 90
IP  - 1
DP  - 2000 Jan
TI  - XYbp, a novel RING-finger protein, is a component of the XY body of spermatocytes
      and centrosomes.
PG  - 95-101
AB  - RING-finger proteins participate in developmental processes, including
      gametogenesis. A fetal oocyte cDNA library was used to select genes expressed
      during male germ-cell differentiation. A novel RING-finger protein, XYbp (XY body
      protein), participating in mouse spermatogenesis has been identified. This novel 
      gene generates a ubiquitously expressed transcript of 4.2 kb and a
      testis-specific one of 2.8 kb, processed by an alternative polyadenylation
      mechanism from a non-canonical polyadenylation signal. Transcription of XYbp is
      regulated during spermatocyte differentiation. The antiserum raised against the
      XYbp peptide demonstrated that XYbp is localised mainly in the XY bivalent of
      spermatocytes (XY body) and in the centrosomes of somatic and germ cells in all
      phases of the cell cycle. These studies indicate that we have identified a new
      member of the RING-finger family of proteins associated with the XY meiotic
      bivalent during spermatogenesis development and with the centrosomes of all
      cells.
FAU - Parraga, M
AU  - Parraga M
AD  - Department of Cell and Developmental Biology, Centro de Invesigaciones Biologicas
      (C.S.I.C.), Velazquez, 144, 28006-, Madrid, Spain.
FAU - del Mazo, J
AU  - del Mazo J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Mech Dev
JT  - Mechanisms of development
JID - 9101218
RN  - 0 (Carrier Proteins)
RN  - 0 (Nuclear Proteins)
RN  - EC 2.3.2.27 (Rnf19 protein, mouse)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Carrier Proteins/*genetics
MH  - Centrosome/*physiology
MH  - Cloning, Molecular
MH  - Female
MH  - Male
MH  - Mice
MH  - Molecular Sequence Data
MH  - Nuclear Proteins/biosynthesis/*genetics
MH  - Spermatocytes/*physiology
MH  - Spermatogenesis
MH  - Ubiquitin-Protein Ligases
EDAT- 1999/12/10 09:00
MHDA- 2000/03/04 09:00
CRDT- 1999/12/10 09:00
PHST- 1999/12/10 09:00 [pubmed]
PHST- 2000/03/04 09:00 [medline]
PHST- 1999/12/10 09:00 [entrez]
AID - S0925-4773(99)00223-3 [pii]
AID - 10.1016/s0925-4773(99)00223-3 [doi]
PST - ppublish
SO  - Mech Dev. 2000 Jan;90(1):95-101. doi: 10.1016/s0925-4773(99)00223-3.