PMID- 10585298
OWN - NLM
STAT- MEDLINE
DCOM- 20000111
LR  - 20161124
IS  - 0014-4827 (Print)
IS  - 0014-4827 (Linking)
VI  - 253
IP  - 2
DP  - 1999 Dec 15
TI  - Fate of mesencephalic AHD2-expressing dopamine progenitor cells in NURR1 mutant
      mice.
PG  - 737-46
AB  - The orphan nuclear receptor NURR1 was previously demonstrated to be required for 
      the generation of mesencephalic dopamine (DA) cells. However, even in the absence
      of NURR1, which is normally expressed as cells become postmitotic, neuronal
      differentiation is induced and expression of several genes detected in developing
      dopamine cells appears normal during early stages of development. These include
      the homeobox transcription factors engrailed and Ptx-3 as well as aldehyde
      dehydrogenase 2, here defined as the earliest marker identified in developing DA 
      cells, expressed already in mitotic DA progenitors. We have used the expression
      of these dopaminergic markers, retrograde axonal tracing, and apoptosis analyses 
      to study the fate of the DA progenitor cells in the absence of NURR1. We conclude
      that NURR1 plays a critical role in the maturation, migration, striatal target
      area innervation, and survival of differentiating mesencephalic DA cells.
CI  - Copyright 1999 Academic Press.
FAU - Wallen, A
AU  - Wallen A
AD  - Ludwig Institute for Cancer Research, Stockholm Branch, Stockholm, S-171 77,
      Sweden.
FAU - Zetterstrom, R H
AU  - Zetterstrom RH
FAU - Solomin, L
AU  - Solomin L
FAU - Arvidsson, M
AU  - Arvidsson M
FAU - Olson, L
AU  - Olson L
FAU - Perlmann, T
AU  - Perlmann T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Exp Cell Res
JT  - Experimental cell research
JID - 0373226
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (NR4A2 protein, human)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Nr4a2 protein, mouse)
RN  - 0 (Nuclear Receptor Subfamily 4, Group A, Member 2)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transcription Factors)
RN  - 0 (engrailed homeobox proteins)
RN  - EC 1.2.1.3 (ALDH2 protein, human)
RN  - EC 1.2.1.3 (Aldehyde Dehydrogenase)
RN  - EC 1.2.1.3 (Aldehyde Dehydrogenase, Mitochondrial)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Aldehyde Dehydrogenase/*genetics
MH  - Aldehyde Dehydrogenase, Mitochondrial
MH  - Animals
MH  - Animals, Newborn
MH  - Cell Differentiation/physiology
MH  - Cell Movement/physiology
MH  - Cell Survival/physiology
MH  - Cells, Cultured
MH  - *DNA-Binding Proteins
MH  - Dopamine/physiology
MH  - Female
MH  - Gene Expression Regulation, Developmental
MH  - Gene Expression Regulation, Enzymologic
MH  - Homeodomain Proteins/genetics
MH  - In Situ Nick-End Labeling
MH  - Male
MH  - Mesencephalon/*cytology
MH  - Mice
MH  - Mice, Mutant Strains
MH  - Nerve Tissue Proteins/genetics
MH  - Neurons/cytology/*enzymology
MH  - Nuclear Receptor Subfamily 4, Group A, Member 2
MH  - RNA, Messenger/analysis
MH  - Stem Cells/cytology/*enzymology
MH  - Transcription Factors/*genetics
MH  - Transcription, Genetic/physiology
EDAT- 1999/12/10 00:00
MHDA- 1999/12/10 00:01
CRDT- 1999/12/10 00:00
PHST- 1999/12/10 00:00 [pubmed]
PHST- 1999/12/10 00:01 [medline]
PHST- 1999/12/10 00:00 [entrez]
AID - 10.1006/excr.1999.4691 [doi]
AID - S0014-4827(99)94691-8 [pii]
PST - ppublish
SO  - Exp Cell Res. 1999 Dec 15;253(2):737-46. doi: 10.1006/excr.1999.4691.