PMID- 10585161
OWN - NLM
STAT- MEDLINE
DCOM- 19991215
LR  - 20191210
IS  - 0891-0618 (Print)
IS  - 0891-0618 (Linking)
VI  - 17
IP  - 2
DP  - 1999 Oct
TI  - Localization of huntingtin-interacting protein-2 (Hip-2) mRNA in the developing
      mouse brain.
PG  - 99-107
AB  - Huntingtin-interacting protein-2 (Hip-2) was identified as a human protein
      specifically associated with huntingtin in vitro, a gene product affected in
      patients with Huntington disease (HD). It is a ubiquitin-conjugating enzyme
      identical to the previously characterized bovine E2-25k. We identified the mouse 
      Hip-2 homologue (mHip-2) and examined its distribution patterns in the developing
      mouse brain in order to gain an insight into the functional significance of the
      Hip-2 protein in the normal brain as well as in the pathogenesis of HD. As
      reported with huntingtin, the mHip-2 mRNA expression developed in parallel with
      neuronal maturation and became distributed widely in the postnatal mouse brain.
      This spatiotemporal pattern of mHip-2 mRNA expression resembled that of
      huntingtin. We further demonstrated that mHip-2 mRNA was colocalized with
      huntingtin-like immunoreactivity in a single neuron. These findings suggested
      that the Hip-2 interacted with huntingtin in vivo and played an important role in
      HD pathogenesis.
FAU - Tanno, Y
AU  - Tanno Y
AD  - Department of Cell Science, Institute of Biomedical Sciences, Fukushima Medical
      University School of Medicine, Fukushima City, Japan. tanno@cc.fmu.ac.jp
FAU - Mori, T
AU  - Mori T
FAU - Yokoya, S
AU  - Yokoya S
FAU - Kanazawa, K
AU  - Kanazawa K
FAU - Honma, Y
AU  - Honma Y
FAU - Nikaido, T
AU  - Nikaido T
FAU - Takeda, J
AU  - Takeda J
FAU - Tojo, M
AU  - Tojo M
FAU - Yamamoto, T
AU  - Yamamoto T
FAU - Wanaka, A
AU  - Wanaka A
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Chem Neuroanat
JT  - Journal of chemical neuroanatomy
JID - 8902615
RN  - 0 (DNA, Complementary)
RN  - 0 (Htt protein, mouse)
RN  - 0 (Huntingtin Protein)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (RNA, Messenger)
RN  - EC 2.3.2.23 (UBE2K protein, human)
RN  - EC 2.3.2.23 (Ubiquitin-Conjugating Enzymes)
RN  - EC 6.- (Ligases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Blotting, Northern
MH  - Brain/anatomy & histology/growth & development/*metabolism
MH  - DNA, Complementary/analysis
MH  - Huntingtin Protein
MH  - In Situ Hybridization
MH  - Ligases/chemistry/*genetics/metabolism
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Molecular Sequence Data
MH  - Nerve Tissue Proteins/metabolism
MH  - Nuclear Proteins/metabolism
MH  - RNA, Messenger/metabolism
MH  - *Ubiquitin-Conjugating Enzymes
EDAT- 1999/12/10 00:00
MHDA- 1999/12/10 00:01
CRDT- 1999/12/10 00:00
PHST- 1999/12/10 00:00 [pubmed]
PHST- 1999/12/10 00:01 [medline]
PHST- 1999/12/10 00:00 [entrez]
AID - S0891061899000307 [pii]
AID - 10.1016/s0891-0618(99)00030-7 [doi]
PST - ppublish
SO  - J Chem Neuroanat. 1999 Oct;17(2):99-107. doi: 10.1016/s0891-0618(99)00030-7.