PMID- 10583958
OWN - NLM
STAT- MEDLINE
DCOM- 19991216
LR  - 20190619
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 286
IP  - 5446
DP  - 1999 Dec 3
TI  - An essential role for BLNK in human B cell development.
PG  - 1954-7
AB  - The signal transduction events that control the progenitor B cell (pro-B cell) to
      precursor B cell (pre-B cell) transition have not been well delineated. In
      evaluating patients with absent B cells, a male with a homozygous splice defect
      in the cytoplasmic adapter protein BLNK (B cell linker protein) was identified.
      Although this patient had normal numbers of pro-B cells, he had no pre-B cells or
      mature B cells, indicating that BLNK plays a critical role in orchestrating the
      pro-B cell to pre-B cell transition. The immune system and overall growth and
      development were otherwise normal in this patient, suggesting that BLNK function 
      is highly specific.
FAU - Minegishi, Y
AU  - Minegishi Y
AD  - Department of Immunology, Department of Hematology-Oncology, St. Jude Children's 
      Research Hospital, Memphis, TN 38105, USA.
FAU - Rohrer, J
AU  - Rohrer J
FAU - Coustan-Smith, E
AU  - Coustan-Smith E
FAU - Lederman, H M
AU  - Lederman HM
FAU - Pappu, R
AU  - Pappu R
FAU - Campana, D
AU  - Campana D
FAU - Chan, A C
AU  - Chan AC
FAU - Conley, M E
AU  - Conley ME
LA  - eng
SI  - GENBANK/AF180740
SI  - GENBANK/AF180741
SI  - GENBANK/AF180742
SI  - GENBANK/AF180743
SI  - GENBANK/AF180744
SI  - GENBANK/AF180745
SI  - GENBANK/AF180746
SI  - GENBANK/AF180747
SI  - GENBANK/AF180748
SI  - GENBANK/AF180749
SI  - GENBANK/AF180750
SI  - GENBANK/AF180751
SI  - GENBANK/AF180752
SI  - GENBANK/AF180753
SI  - GENBANK/AF180754
SI  - GENBANK/AF180755
SI  - GENBANK/AF180756
GR  - AI25129/AI/NIAID NIH HHS/United States
GR  - AI42787/AI/NIAID NIH HHS/United States
GR  - CA71516/CA/NCI NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Antigens, CD19)
RN  - 0 (Antigens, CD34)
RN  - 0 (B cell linker protein)
RN  - 0 (Carrier Proteins)
RN  - 0 (Phosphoproteins)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.2 (Agammaglobulinaemia Tyrosine Kinase)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Adult
MH  - Agammaglobulinaemia Tyrosine Kinase
MH  - Agammaglobulinemia/*genetics/immunology
MH  - Antigens, CD19/analysis
MH  - Antigens, CD34/analysis
MH  - B-Lymphocytes/*cytology
MH  - Bone Marrow Cells/cytology
MH  - Carrier Proteins/genetics/*physiology
MH  - Cell Differentiation
MH  - Chromosome Mapping
MH  - Gene Rearrangement, B-Lymphocyte, Heavy Chain
MH  - Hematopoietic Stem Cells/*cytology
MH  - Humans
MH  - Male
MH  - Molecular Sequence Data
MH  - *Phosphoproteins
MH  - Point Mutation
MH  - Protein-Tyrosine Kinases/genetics/physiology
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Signal Transduction
EDAT- 1999/12/03 00:00
MHDA- 1999/12/03 00:01
CRDT- 1999/12/03 00:00
PHST- 1999/12/03 00:00 [pubmed]
PHST- 1999/12/03 00:01 [medline]
PHST- 1999/12/03 00:00 [entrez]
AID - 8048 [pii]
AID - 10.1126/science.286.5446.1954 [doi]
PST - ppublish
SO  - Science. 1999 Dec 3;286(5446):1954-7. doi: 10.1126/science.286.5446.1954.