PMID- 10582682
OWN - NLM
STAT- MEDLINE
DCOM- 19991214
LR  - 20171116
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 59
IP  - 22
DP  - 1999 Nov 15
TI  - Point mutations and deletions of the Bcl10 gene in solid tumors and malignant
      lymphomas.
PG  - 5674-7
AB  - The Bcl10 gene, which encodes a protein with proapoptotic activity, recently has 
      been identified on chromosome 1p22. In this study, we analyzed somatic mutations 
      and deletions of the Bcl10 gene in a series of 439 tumor tissues from various
      histological origins that are known to have frequent loss of heterozygosity at
      chromosome 1p22. According to the LOH study at intragenic polymorphic sites,
      deletion of Bcl10 in informative cases was detected in 50% of malignant
      mesotheliomas, 33% of gastric carcinomas, 23% of breast carcinomas, 20% of
      hepatocellular carcinomas, 17% of lymphomas, 15% of colorectal carcinomas, 13% of
      laryngeal carcinomas, and 10% of male germ cell tumors (GCTs). In contrast, we
      detected Bcl10 mutations in 4 of 120 lymphomas (3.3%) and 2 of 78 GCTs (2.6%),
      respectively, but no mutation was found in the remaining solid tumors analyzed.
      Taken together, these data imply that Bcl10 may occasionally be involved in the
      pathogenesis of lymphoma and GCTs. However, the absence or low frequency of the
      mutation suggests that either Bcl10 is inactivated by other mechanisms or it is
      not the only target of chromosome 1p22 deletion in human tumors.
FAU - Lee, S H
AU  - Lee SH
AD  - Department of Pathology, College of Medicine, The Catholic University of Korea,
      Seoul.
FAU - Shin, M S
AU  - Shin MS
FAU - Kim, H S
AU  - Kim HS
FAU - Park, W S
AU  - Park WS
FAU - Kim, S Y
AU  - Kim SY
FAU - Lee, H K
AU  - Lee HK
FAU - Park, J Y
AU  - Park JY
FAU - Oh, R R
AU  - Oh RR
FAU - Jang, J J
AU  - Jang JJ
FAU - Park, K M
AU  - Park KM
FAU - Han, J Y
AU  - Han JY
FAU - Kang, C S
AU  - Kang CS
FAU - Lee, J Y
AU  - Lee JY
FAU - Yoo, N J
AU  - Yoo NJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (B-Cell CLL-Lymphoma 10 Protein)
RN  - 0 (BCL10 protein, human)
RN  - 0 (Neoplasm Proteins)
SB  - IM
MH  - *Adaptor Proteins, Signal Transducing
MH  - B-Cell CLL-Lymphoma 10 Protein
MH  - Breast Neoplasms/genetics
MH  - Carcinoma, Ductal, Breast/genetics
MH  - Carcinoma, Squamous Cell/genetics
MH  - Chromosomes, Human, Pair 1/*genetics
MH  - Colorectal Neoplasms/genetics
MH  - *Gene Deletion
MH  - Germinoma/genetics
MH  - Humans
MH  - Laryngeal Neoplasms/genetics
MH  - Lymphoma, B-Cell/genetics
MH  - Lymphoma, T-Cell/genetics
MH  - Neoplasm Proteins/*genetics
MH  - Neoplasms/*genetics
MH  - Point Mutation/*genetics
EDAT- 1999/12/03 00:00
MHDA- 1999/12/03 00:01
CRDT- 1999/12/03 00:00
PHST- 1999/12/03 00:00 [pubmed]
PHST- 1999/12/03 00:01 [medline]
PHST- 1999/12/03 00:00 [entrez]
PST - ppublish
SO  - Cancer Res. 1999 Nov 15;59(22):5674-7.