PMID- 10582680
OWN - NLM
STAT- MEDLINE
DCOM- 19991214
LR  - 20071114
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 59
IP  - 22
DP  - 1999 Nov 15
TI  - Gender differences in p53 mutational status in small cell lung cancer.
PG  - 5666-70
AB  - Mutations in the p53 tumor suppressor gene have been demonstrated to be one of
      the most frequent genetic abnormalities in human cancers. Previous studies have
      shown that the frequency of p53 mutations is significantly higher in small cell
      lung cancer than in non-small cell lung cancer. However, this conclusion was
      based in large part on data derived from tumor cell lines and from studies with
      relatively small sample sizes and biased gender populations. To determine the
      mutational frequency in the p53 tumor suppressor gene and a potential difference 
      in gender, we analyzed primary small cell lung cancer tumors from 65 patients (37
      males and 28 females) for p53 mutations between exons 5 and 9. Mutations were
      found in 37 of 65 tumors (57%) within the region of p53 analyzed. Interestingly, 
      none of the tumors from females contained more than one mutation, whereas four of
      the tumors from males contained more than one mutation. The most common mutation 
      in this population was an adenosine-to-guanine transition (27%), followed by
      guanine-to-thymidine transversion (17%) and guanine-to-adenosine transition
      (12%). The gender difference in p53 mutational rate identified in this study
      suggests that a higher proportion of female tumors may develop through pathways
      not involving p53 mutations.
FAU - Tseng, J E
AU  - Tseng JE
AD  - Department of Thoracic/Head and Neck Medical Oncology, University of Texas M.D.
      Anderson Cancer Center, Houston 77030, USA.
FAU - Rodriguez, M
AU  - Rodriguez M
FAU - Ro, J
AU  - Ro J
FAU - Liu, D
AU  - Liu D
FAU - Hong, W K
AU  - Hong WK
FAU - Mao, L
AU  - Mao L
LA  - eng
GR  - P30 CA16620/CA/NCI NIH HHS/United States
GR  - U19 CA68437/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Small Cell/*genetics
MH  - Exons/genetics
MH  - Female
MH  - Genes, p53/*genetics
MH  - Humans
MH  - Introns/genetics
MH  - Lung Neoplasms/*genetics
MH  - Male
MH  - Middle Aged
MH  - Mutation, Missense/*genetics
MH  - Sequence Deletion
MH  - Sex Factors
MH  - Smoking/adverse effects
EDAT- 1999/12/03 00:00
MHDA- 1999/12/03 00:01
CRDT- 1999/12/03 00:00
PHST- 1999/12/03 00:00 [pubmed]
PHST- 1999/12/03 00:01 [medline]
PHST- 1999/12/03 00:00 [entrez]
PST - ppublish
SO  - Cancer Res. 1999 Nov 15;59(22):5666-70.