PMID- 10582623
OWN - NLM
STAT- MEDLINE
DCOM- 19991227
LR  - 20190630
IS  - 0022-3042 (Print)
IS  - 0022-3042 (Linking)
VI  - 73
IP  - 6
DP  - 1999 Dec
TI  - A novel rat tetraspan protein in cells of the oligodendrocyte lineage.
PG  - 2600-8
AB  - The tetraspanin/transmembrane 4 superfamily gene superfamily encodes proteins
      that span the plasma membrane four times. Tetraspan proteins are implicated in
      proliferation, motility, and differentiation in various cell types, and in some
      cells they may link plasma membrane proteins into signalling complexes. Using a
      subtractive cDNA library prepared from oligodendrocytes and their progenitor
      cells, we have identified Tspan-2 as a member of this superfamily. In situ
      hybridization analysis revealed robust expression in cells of the oligodendrocyte
      lineage in comparison with the Plp gene, a well-characterized marker for
      myelin-forming glia in the CNS. Rat Tspan-2 mRNA is restricted to the nervous
      system and is detectable by northern blot shortly after birth in the CNS.
      Subsequently the gene is up-regulated strongly between postnatal day 3 and 10,
      and expression levels continue to rise up to postnatal day 22. These data
      indicate that Tspan-2 is likely to play a role in signalling in oligodendrocytes 
      in the early stages of their terminal differentiation into myelin-forming glia
      and may also function in stabilizing the mature sheath.
FAU - Birling, M C
AU  - Birling MC
AD  - Department of Preclinical Veterinary Sciences, University of Edinburgh, Scotland.
FAU - Tait, S
AU  - Tait S
FAU - Hardy, R J
AU  - Hardy RJ
FAU - Brophy, P J
AU  - Brophy PJ
LA  - eng
SI  - GENBANK/AJ271442
GR  - Wellcome Trust/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (DNA, Complementary)
RN  - 0 (Membrane Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tetraspanins)
RN  - 0 (Tspan2 protein, rat)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Brain/cytology/growth & development/*metabolism
MH  - Cell Differentiation
MH  - Cell Lineage
MH  - DNA, Complementary/genetics
MH  - Gene Expression Regulation, Developmental
MH  - In Situ Hybridization
MH  - Membrane Proteins/biosynthesis/genetics/*isolation & purification
MH  - Molecular Sequence Data
MH  - Multigene Family
MH  - Myelin Sheath/physiology
MH  - Nerve Tissue Proteins/biosynthesis/genetics/*isolation & purification
MH  - Oligodendroglia/*metabolism
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Rats
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Tetraspanins
EDAT- 1999/12/03 00:00
MHDA- 1999/12/03 00:01
CRDT- 1999/12/03 00:00
PHST- 1999/12/03 00:00 [pubmed]
PHST- 1999/12/03 00:01 [medline]
PHST- 1999/12/03 00:00 [entrez]
AID - 10.1046/j.1471-4159.1999.0732600.x [doi]
PST - ppublish
SO  - J Neurochem. 1999 Dec;73(6):2600-8. doi: 10.1046/j.1471-4159.1999.0732600.x.