PMID- 10582583
OWN - NLM
STAT- MEDLINE
DCOM- 19991227
LR  - 20190630
IS  - 0022-3042 (Print)
IS  - 0022-3042 (Linking)
VI  - 73
IP  - 6
DP  - 1999 Dec
TI  - Characterization of transcripts from the synapsin III gene locus.
PG  - 2266-71
AB  - Synapsin III, the most recently described member of the synapsin gene family,
      displays a gene structure and protein domain structure similar to those of
      synapsins I and II. In this report, however, we describe major differences in the
      temporal- and tissue-specific expressions of synapsin III. Whereas synapsins I
      and II each give rise to two isoforms that are expressed predominantly in adult
      brain, there are at least six synapsin III transcripts (synapsin IIIa-IIIf) that 
      differ with respect to tissue- and developmental stage-specific expression. Three
      of the neuronal transcripts are detected in fetal and to a lesser extent in adult
      brain (IIa-IIIc), whereas one (IIId) is detected only in fetal brain. Two
      additional transcripts (IIIe and IIIf) are detected only in nonneuronal tissues. 
      A putative second promoter, which is contained within an intron in the synapsin
      III gene locus, appears to generate the nonneuronal synapsin IIIe and IIIf
      transcripts. This level of genome complexity is far greater than that described
      previously for the synapsin I and II genes and suggests that synapsin III may
      have functions distinct from those described for synapsins I and II.
FAU - Porton, B
AU  - Porton B
AD  - Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New
      York, New York 10021-6399, USA.
FAU - Kao, H T
AU  - Kao HT
FAU - Greengard, P
AU  - Greengard P
LA  - eng
SI  - GENBANK/AA234705
SI  - GENBANK/AA868571
SI  - GENBANK/AA992358
GR  - MH39327/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (Protein Isoforms)
RN  - 0 (RNA, Messenger)
RN  - 0 (Synapsins)
SB  - IM
MH  - Animals
MH  - Blotting, Northern
MH  - Blotting, Western
MH  - Brain/metabolism
MH  - Expressed Sequence Tags
MH  - *Gene Expression Regulation
MH  - Male
MH  - Mice
MH  - Mice, Knockout
MH  - Molecular Sequence Data
MH  - Organ Specificity
MH  - Polymerase Chain Reaction
MH  - Protein Isoforms/*genetics
MH  - Protein Structure, Tertiary
MH  - RNA, Messenger/*genetics
MH  - Synapsins/biosynthesis/chemistry/*genetics
MH  - Transcription, Genetic
EDAT- 1999/12/03 00:00
MHDA- 1999/12/03 00:01
CRDT- 1999/12/03 00:00
PHST- 1999/12/03 00:00 [pubmed]
PHST- 1999/12/03 00:01 [medline]
PHST- 1999/12/03 00:00 [entrez]
AID - 10.1046/j.1471-4159.1999.0732266.x [doi]
PST - ppublish
SO  - J Neurochem. 1999 Dec;73(6):2266-71. doi: 10.1046/j.1471-4159.1999.0732266.x.