PMID- 10582581
OWN - NLM
STAT- MEDLINE
DCOM- 19991227
LR  - 20190828
IS  - 0022-3042 (Print)
IS  - 0022-3042 (Linking)
VI  - 73
IP  - 6
DP  - 1999 Dec
TI  - Identification of a mammalian homologue of the fungal Tom70 mitochondrial
      precursor protein import receptor as a thyroid hormone-regulated gene in specific
      brain regions.
PG  - 2240-9
AB  - Thyroid hormone is an important regulator of mammalian brain maturation. By
      differential display PCR, we isolated a cDNA clone (S2) that is specifically
      up-regulated in the striatum of neonatal hypothyroid rats. S2 was identified as
      KIAA0719, the first human gene distantly homologous to the fungal Tom70, which
      encodes a member of the translocase mitochondrial outer membrane complex involved
      in the import of preproteins into the mitochondria. By northern and in situ
      hybridization studies, KIAA0719 was found to be up-regulated in the striatum,
      nucleus accumbens, and discrete cortical layers of 15-day-old hypothyroid rats.
      In contrast, lower expression was found in the olfactory tubercle, whereas no
      differences were detected in other brain regions. Significantly, treatment of
      hypothyroid animals with single injections of thyroxine restored the normal
      levels of KIAA0719 expression. Moreover, treatment of control animals with
      thyroxine led to a reduced expression, demonstrating a negative hormonal
      regulation in vivo. Thus, KIAA0719 gene expression is regulated by thyroid
      hormone in the neonatal rat brain in a region-specific fashion. Given the role of
      the homologous Tom70 gene, the alteration of KIAA0719 expression may contribute
      to the changes in mitochondrial morphology and physiology caused by
      hypothyroidism in the developing rat brain.
FAU - Alvarez-Dolado, M
AU  - Alvarez-Dolado M
AD  - Instituto de Investigaciones Biomedicas "Alberto Sols," Consejo Superior de
      Investigaciones Cientificas (CSIC)-Universidad Autonoma de Madrid (UAM), Spain.
FAU - Gonzalez-Moreno, M
AU  - Gonzalez-Moreno M
FAU - Valencia, A
AU  - Valencia A
FAU - Zenke, M
AU  - Zenke M
FAU - Bernal, J
AU  - Bernal J
FAU - Munoz, A
AU  - Munoz A
LA  - eng
SI  - GENBANK/AJ243368
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (Fungal Proteins)
RN  - 0 (KIAAO719 protein, rat)
RN  - 0 (Membrane Proteins)
RN  - 0 (Membrane Transport Proteins)
RN  - 0 (Mitochondrial Membrane Transport Proteins)
RN  - 0 (Mitochondrial Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Saccharomyces cerevisiae Proteins)
RN  - 0 (TOM70 protein, S cerevisiae)
RN  - 0 (TOMM70 protein, human)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Brain/*metabolism
MH  - Fungal Proteins/*chemistry
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation, Developmental/*drug effects
MH  - Genes
MH  - Humans
MH  - Hypothyroidism/chemically induced/*metabolism
MH  - In Situ Hybridization
MH  - Membrane Proteins/*chemistry/genetics/*isolation & purification/physiology
MH  - *Membrane Transport Proteins
MH  - Mitochondria/metabolism
MH  - Mitochondrial Membrane Transport Proteins
MH  - Mitochondrial Proteins
MH  - Molecular Sequence Data
MH  - RNA, Messenger/biosynthesis
MH  - Rats
MH  - Rats, Wistar
MH  - Saccharomyces cerevisiae/genetics
MH  - *Saccharomyces cerevisiae Proteins
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Subtraction Technique
MH  - Thyroid Gland/*physiology
MH  - Thyroxine/*pharmacology
EDAT- 1999/12/03 00:00
MHDA- 1999/12/03 00:01
CRDT- 1999/12/03 00:00
PHST- 1999/12/03 00:00 [pubmed]
PHST- 1999/12/03 00:01 [medline]
PHST- 1999/12/03 00:00 [entrez]
AID - 10.1046/j.1471-4159.1999.0732240.x [doi]
PST - ppublish
SO  - J Neurochem. 1999 Dec;73(6):2240-9. doi: 10.1046/j.1471-4159.1999.0732240.x.