PMID- 10581368
OWN - NLM
STAT- MEDLINE
DCOM- 20000106
LR  - 20190610
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1461
IP  - 2
DP  - 1999 Dec 6
TI  - Conjugate export pumps of the multidrug resistance protein (MRP) family:
      localization, substrate specificity, and MRP2-mediated drug resistance.
PG  - 377-94
AB  - The membrane proteins mediating the ATP-dependent transport of lipophilic
      substances conjugated to glutathione, glucuronate, or sulfate have been
      identified as members of the multidrug resistance protein (MRP) family. Several
      isoforms of these conjugate export pumps with different kinetic properties and
      domain-specific localization in polarized human cells have been cloned and
      characterized. Orthologs of the human MRP isoforms have been detected in many
      different organisms. Studies in mutant rats lacking the apical isoform MRP2
      (symbol ABCC2) indicate that anionic conjugates of endogenous and exogenous
      substances cannot exit from cells at a sufficient rate unless an export pump of
      the MRP family is present in the plasma membrane. Several mutations in the human 
      MRP2 gene have been identified which lead to the absence of the MRP2 protein from
      the hepatocyte canalicular membrane and to the conjugated hyperbilirubinemia of
      Dubin-Johnson syndrome. Overexpression of recombinant MRP2 confers resistance to 
      multiple chemotherapeutic agents. Because of its function in the terminal
      excretion of cytotoxic and carcinogenic substances, MRP2 as well as other members
      of the MRP family, play an important role in detoxification and chemoprevention.
FAU - Konig, J
AU  - Konig J
AD  - Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, D-69120,
      Heidelberg, Germany.
FAU - Nies, A T
AU  - Nies AT
FAU - Cui, Y
AU  - Cui Y
FAU - Leier, I
AU  - Leier I
FAU - Keppler, D
AU  - Keppler D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B)
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (Isoenzymes)
RN  - 0 (Membrane Transport Proteins)
RN  - 0 (Multidrug Resistance-Associated Proteins)
RN  - 1YV0492L5Z (multidrug resistance-associated protein 3)
RN  - 4AF605U6JN (multidrug resistance-associated protein 2)
RN  - Y49M64GZ4Q (multidrug resistance-associated protein 1)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily B/*chemistry/genetics/metabolism
MH  - ATP-Binding Cassette Transporters/*chemistry/genetics/metabolism
MH  - Animals
MH  - Cell Line
MH  - Cell Membrane/chemistry
MH  - Drug Resistance, Multiple
MH  - Gene Expression Regulation
MH  - Humans
MH  - Isoenzymes/chemistry
MH  - Jaundice, Chronic Idiopathic/genetics
MH  - Kinetics
MH  - Liver/metabolism
MH  - *Membrane Transport Proteins
MH  - Multidrug Resistance-Associated Proteins
MH  - Substrate Specificity
RF  - 138
EDAT- 1999/12/03 00:00
MHDA- 1999/12/03 00:01
CRDT- 1999/12/03 00:00
PHST- 1999/12/03 00:00 [pubmed]
PHST- 1999/12/03 00:01 [medline]
PHST- 1999/12/03 00:00 [entrez]
AID - S0005-2736(99)00169-8 [pii]
AID - 10.1016/s0005-2736(99)00169-8 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 1999 Dec 6;1461(2):377-94. doi:
      10.1016/s0005-2736(99)00169-8.