PMID- 10581366
OWN - NLM
STAT- MEDLINE
DCOM- 20000106
LR  - 20190610
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1461
IP  - 2
DP  - 1999 Dec 6
TI  - The multidrug resistance protein family.
PG  - 347-57
AB  - The human multidrug resistance protein (MRP) family contains at least six
      members: MRP1, the godfather of the family and well known as the multidrug
      resistance protein, and five homologs, called MRP2-6. In this review, we
      summarize what is known about the protein structure, the expression in tissues,
      the routing in cells, the physiological functions, the substrate specificity, and
      the role in multidrug resistance of the individual members of the MRP family.
FAU - Borst, P
AU  - Borst P
AD  - Division of Molecular Biology and Center for Biomedical Genetics, The Netherlands
      Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, Netherlands. pborst@nki.nl
FAU - Evers, R
AU  - Evers R
FAU - Kool, M
AU  - Kool M
FAU - Wijnholds, J
AU  - Wijnholds J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 1)
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (Anion Transport Proteins)
RN  - 0 (Carrier Proteins)
RN  - 0 (Membrane Transport Proteins)
RN  - 0 (Multidrug Resistance-Associated Proteins)
RN  - 1YV0492L5Z (multidrug resistance-associated protein 3)
RN  - 4AF605U6JN (multidrug resistance-associated protein 2)
RN  - GAN16C9B8O (Glutathione)
RN  - Y49M64GZ4Q (multidrug resistance-associated protein 1)
SB  - IM
SB  - S
MH  - ATP Binding Cassette Transporter, Subfamily B/genetics
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 1/*genetics/metabolism
MH  - ATP-Binding Cassette Transporters/*genetics/metabolism
MH  - Animals
MH  - Anion Transport Proteins
MH  - Carrier Proteins/genetics
MH  - Cell Line
MH  - Cell Membrane/metabolism
MH  - Drug Resistance, Multiple/*genetics
MH  - Glutathione/metabolism
MH  - Humans
MH  - *Membrane Transport Proteins
MH  - Models, Molecular
MH  - Multidrug Resistance-Associated Proteins
MH  - Phylogeny
MH  - Terminology as Topic
MH  - Transfection
EDAT- 1999/12/03 00:00
MHDA- 1999/12/03 00:01
CRDT- 1999/12/03 00:00
PHST- 1999/12/03 00:00 [pubmed]
PHST- 1999/12/03 00:01 [medline]
PHST- 1999/12/03 00:00 [entrez]
AID - S0005-2736(99)00167-4 [pii]
AID - 10.1016/s0005-2736(99)00167-4 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 1999 Dec 6;1461(2):347-57. doi:
      10.1016/s0005-2736(99)00167-4.