PMID- 10581359
OWN - NLM
STAT- MEDLINE
DCOM- 20000106
LR  - 20190610
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1461
IP  - 2
DP  - 1999 Dec 6
TI  - An inventory of the human ABC proteins.
PG  - 237-62
AB  - Currently 30 human ABC proteins are represented by full sequences in various
      databases, and this paper provides a brief overview of these proteins. ABC
      proteins are composed of transmembrane domains (TMDs), and nucleotide binding
      domains (NBDs, or ATP-binding cassettes, ABSs). The arrangement of these domains,
      together with available membrane topology models of the family members, are
      presented. Based on their sequence similarity scores, the members of the human
      ABC protein family can be grouped into eight subfamilies. At present the MDR/TAP,
      the ALD, the MRP/CFTR, the ABC1, the White, the RNAseL inhibitor, the ANSA, and
      the GCN20 subfamilies are identified. Mutations of many human ABC proteins are
      known to be causative in inherited diseases, and a short description of the
      molecular pathology of these ABC gene-related genetic diseases is also provided.
FAU - Klein, I
AU  - Klein I
AD  - Institute of Enzymology, Biological Research Center, Hungarian Academy of
      Sciences, H-1502, Budapest, Hungary.
FAU - Sarkadi, B
AU  - Sarkadi B
FAU - Varadi, A
AU  - Varadi A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (ABCA1 protein, human)
RN  - 0 (ABCF1 protein, human)
RN  - 0 (ATP Binding Cassette Transporter 1)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 1)
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (CFTR protein, human)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Glycoproteins)
RN  - 0 (MSH3 protein, human)
RN  - 0 (Membrane Proteins)
RN  - 0 (Multidrug Resistance-Associated Proteins)
RN  - 0 (MutS Homolog 3 Protein)
RN  - 126880-72-6 (Cystic Fibrosis Transmembrane Conductance Regulator)
RN  - Y49M64GZ4Q (multidrug resistance-associated protein 1)
SB  - IM
MH  - ATP Binding Cassette Transporter 1
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 1/genetics
MH  - ATP-Binding Cassette Transporters/chemistry/*classification/genetics
MH  - Cystic Fibrosis Transmembrane Conductance Regulator/genetics
MH  - DNA-Binding Proteins/genetics
MH  - Glycoproteins/genetics
MH  - Humans
MH  - Membrane Proteins/*genetics
MH  - *Multidrug Resistance-Associated Proteins
MH  - MutS Homolog 3 Protein
MH  - Sequence Alignment
RF  - 138
EDAT- 1999/12/03 00:00
MHDA- 1999/12/03 00:01
CRDT- 1999/12/03 00:00
PHST- 1999/12/03 00:00 [pubmed]
PHST- 1999/12/03 00:01 [medline]
PHST- 1999/12/03 00:00 [entrez]
AID - S0005-2736(99)00161-3 [pii]
AID - 10.1016/s0005-2736(99)00161-3 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 1999 Dec 6;1461(2):237-62. doi:
      10.1016/s0005-2736(99)00161-3.