PMID- 10581279
OWN - NLM
STAT- MEDLINE
DCOM- 20000208
LR  - 20211012
IS  - 0016-6731 (Print)
IS  - 0016-6731 (Linking)
VI  - 153
IP  - 4
DP  - 1999 Dec
TI  - Large number of replacement polymorphisms in rapidly evolving genes of 
      Drosophila. Implications for genome-wide surveys of DNA polymorphism.
PG  - 1717-29
AB  - We present a survey of nucleotide polymorphism of three novel, rapidly evolving 
      genes in populations of Drosophila melanogaster and D. simulans. Levels of silent 
      polymorphism are comparable to other loci, but the number of replacement 
      polymorphisms is higher than that in most other genes surveyed in D. melanogaster 
      and D. simulans. Tests of neutrality fail to reject neutral evolution with one 
      exception. This concerns a gene located in a region of high recombination rate in 
      D. simulans and in a region of low recombination rate in D. melanogaster, due to 
      an inversion. In the latter case it shows a very low number of polymorphisms, 
      presumably due to selective sweeps in the region. Patterns of nucleotide 
      polymorphism suggest that most substitutions are neutral or nearly neutral and 
      that weak (positive and purifying) selection plays a significant role in the 
      evolution of these genes. At all three loci, purifying selection of slightly 
      deleterious replacement mutations appears to be more efficient in D. simulans 
      than in D. melanogaster, presumably due to different effective population sizes. 
      Our analysis suggests that current knowledge about genome-wide patterns of 
      nucleotide polymorphism is far from complete with respect to the types and range 
      of nucleotide substitutions and that further analysis of differences between 
      local populations will be required to understand the forces more completely. We 
      note that rapidly diverging and nearly neutrally evolving genes cannot be 
      expected only in the genome of Drosophila, but are likely to occur in large 
      numbers also in other organisms and that their function and evolution are little 
      understood so far.
FAU - Schmid, K J
AU  - Schmid KJ
AD  - Zoologisches Institut, Universitat Munchen, 80333 Munchen, Germany. 
      kjs21@cornell.edu
FAU - Nigro, L
AU  - Nigro L
FAU - Aquadro, C F
AU  - Aquadro CF
FAU - Tautz, D
AU  - Tautz D
LA  - eng
SI  - GENBANK/AF161723
SI  - GENBANK/AF161724
SI  - GENBANK/AF161725
SI  - GENBANK/AF161726
SI  - GENBANK/AF161727
SI  - GENBANK/AF161728
SI  - GENBANK/AF161729
SI  - GENBANK/AF161730
SI  - GENBANK/AF161731
SI  - GENBANK/AF161732
SI  - GENBANK/AF161733
SI  - GENBANK/AF161734
SI  - GENBANK/AF161735
SI  - GENBANK/AF161736
SI  - GENBANK/AF161737
SI  - GENBANK/AF161738
SI  - GENBANK/AF161739
SI  - GENBANK/AF161740
SI  - GENBANK/AF161741
SI  - GENBANK/AF161742
SI  - GENBANK/AF161743
SI  - GENBANK/AF161744
SI  - GENBANK/AF161745
SI  - GENBANK/AF161746
SI  - GENBANK/AF161747
SI  - GENBANK/AF161748
SI  - GENBANK/AF161749
SI  - GENBANK/AF161750
SI  - GENBANK/AF161751
SI  - GENBANK/AF161752
GR  - R01 GM036431/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genetics
JT  - Genetics
JID - 0374636
RN  - 0 (DNA Primers)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Biological Evolution
MH  - DNA/*genetics
MH  - DNA Primers
MH  - Drosophila/*genetics
MH  - *Genome
MH  - In Situ Hybridization
MH  - *Polymorphism, Genetic
MH  - Species Specificity
PMC - PMC1460855
EDAT- 1999/12/03 00:00
MHDA- 1999/12/03 00:01
CRDT- 1999/12/03 00:00
PHST- 1999/12/03 00:00 [pubmed]
PHST- 1999/12/03 00:01 [medline]
PHST- 1999/12/03 00:00 [entrez]
AID - 10.1093/genetics/153.4.1717 [doi]
PST - ppublish
SO  - Genetics. 1999 Dec;153(4):1717-29. doi: 10.1093/genetics/153.4.1717.