PMID- 10581191
OWN - NLM
STAT- MEDLINE
DCOM- 20000106
LR  - 20191210
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 266
IP  - 1
DP  - 1999 Dec 9
TI  - Identification of new genes ndr2 and ndr3 which are related to Ndr1/RTP/Drg1 but 
      show distinct tissue specificity and response to N-myc.
PG  - 208-15
AB  - Ndr1 was isolated as a gene upregulated in N-myc mutant mouse embryos and is
      repressed by N-myc and c-myc. Consistent with Myc regulation, the same gene was
      also isolated as one sensitive to transformation (Drg1), and in addition as one
      induced under a few stress conditions (RTP). Two new genes, Ndr2 and Ndr3, were
      identified which encode proteins highly related to Ndr1/RTP/Drg1 and constitute
      the Ndr gene family. Ndr2 and Ndr3 are under spatio-temporal regulations distinct
      from Ndr1, and are not activated in N-myc mutants. When whole embryo RNA was
      analyzed, Ndr3 expression was already high at 9.5 days postcoitus (dpc), while
      expression of Ndr2 and Ndr1 became significant after 12.5 dpc and 13. 5 dpc,
      respectively. At 14.5 dpc, expression of these genes partially overlaps, but many
      tissues are unique to one of them. For instance, Ndr1 is strongly expressed in
      the liver and gut epithelium, Ndr2 in the ventricular zone throughout the CNS,
      and Ndr3 in the spinal cord and the thymus rudiment. Genes of the Ndr family
      probably have tissue-dependent allotments of the possibly related functions.
CI  - Copyright 1999 Academic Press.
FAU - Okuda, T
AU  - Okuda T
AD  - Institute for Molecular and Cellular Biology, Osaka University, 1-3 Yamadaoka,
      Suita, Osaka, 565-0871, Japan.
FAU - Kondoh, H
AU  - Kondoh H
LA  - eng
SI  - GENBANK/AB033921
SI  - GENBANK/AB033922
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Ndr2 protein, mouse)
RN  - 0 (Ndr2 protein, vertebrate)
RN  - 0 (Ndrg3 protein, mouse)
RN  - 0 (Nodal Signaling Ligands)
RN  - 0 (Proteins)
RN  - 0 (Proto-Oncogene Proteins c-myc)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cloning, Molecular
MH  - Embryo, Mammalian/metabolism
MH  - Expressed Sequence Tags
MH  - Gene Deletion
MH  - *Gene Expression Regulation, Developmental
MH  - In Situ Hybridization
MH  - Intracellular Signaling Peptides and Proteins
MH  - Limb Buds/embryology/metabolism
MH  - Mice
MH  - Molecular Sequence Data
MH  - Nodal Signaling Ligands
MH  - Organ Specificity
MH  - Proteins/chemistry/*genetics/metabolism
MH  - Proto-Oncogene Proteins c-myc/genetics/*metabolism
MH  - RNA, Messenger/analysis/genetics
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Transforming Growth Factor beta/*chemistry/*genetics/metabolism
EDAT- 1999/12/03 00:00
MHDA- 1999/12/03 00:01
CRDT- 1999/12/03 00:00
PHST- 1999/12/03 00:00 [pubmed]
PHST- 1999/12/03 00:01 [medline]
PHST- 1999/12/03 00:00 [entrez]
AID - 10.1006/bbrc.1999.1780 [doi]
AID - S0006-291X(99)91780-1 [pii]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1999 Dec 9;266(1):208-15. doi:
      10.1006/bbrc.1999.1780.