PMID- 10581077
OWN - NLM
STAT- MEDLINE
DCOM- 19991229
LR  - 20181130
IS  - 1078-8956 (Print)
IS  - 1078-8956 (Linking)
VI  - 5
IP  - 12
DP  - 1999 Dec
TI  - B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and
      interleukin-10 secretion.
PG  - 1365-9
AB  - The B7 family members B7-1 and B7-2 interact with CD28 and constitute an
      essential T-cell co-stimulatory pathway in the initiation of antigen-specific
      humoral and cell-mediated immune response. Here, we describe a third member of
      the B7 family, called B7-H1 that does not bind CD28, cytotoxic T-lymphocyte A4 or
      ICOS (inducible co-stimulator). Ligation of B7-H1 co-stimulated T-cell responses 
      to polyclonal stimuli and allogeneic antigens, and preferentially stimulated the 
      production of interleukin-10. Interleukin-2, although produced in small amounts, 
      was required for the effect of B7-H1 co-stimulation. Our studies thus define a
      previously unknown co-stimulatory molecule that may be involved in the negative
      regulation of cell-mediated immune responses.
FAU - Dong, H
AU  - Dong H
AD  - Department of Immunology, Mayo Graduate and Medical Schools, Mayo Clinic, 200
      First Street SW, Rochester, Minnesota 55905, USA.
FAU - Zhu, G
AU  - Zhu G
FAU - Tamada, K
AU  - Tamada K
FAU - Chen, L
AU  - Chen L
LA  - eng
SI  - GENBANK/AF177937
GR  - CA09127/CA/NCI NIH HHS/United States
GR  - CA79915/CA/NCI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Nat Med
JT  - Nature medicine
JID - 9502015
RN  - 0 (B7-1 Antigen)
RN  - 0 (DNA, Complementary)
RN  - 0 (Interleukin-2)
RN  - 0 (Recombinant Proteins)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
CIN - Nat Med. 1999 Dec;5(12):1345-6. PMID: 10581066
MH  - Amino Acid Sequence
MH  - Animals
MH  - B7-1 Antigen/genetics/*immunology
MH  - Cell Line
MH  - Cloning, Molecular
MH  - DNA, Complementary/genetics
MH  - Gene Expression
MH  - Humans
MH  - Immunity, Cellular
MH  - In Vitro Techniques
MH  - Interleukin-10/biosynthesis/*metabolism
MH  - Interleukin-2/biosynthesis
MH  - Lymphocyte Activation
MH  - Molecular Sequence Data
MH  - Recombinant Proteins/genetics/immunology
MH  - Sequence Homology, Amino Acid
MH  - T-Lymphocytes/*immunology
MH  - Transfection
EDAT- 1999/12/02 09:00
MHDA- 2001/03/23 10:01
CRDT- 1999/12/02 09:00
PHST- 1999/12/02 09:00 [pubmed]
PHST- 2001/03/23 10:01 [medline]
PHST- 1999/12/02 09:00 [entrez]
AID - 10.1038/70932 [doi]
PST - ppublish
SO  - Nat Med. 1999 Dec;5(12):1365-9. doi: 10.1038/70932.