PMID- 10580103
OWN - NLM
STAT- MEDLINE
DCOM- 20000113
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 462
IP  - 1-2
DP  - 1999 Nov 26
TI  - Two tetrodotoxin-resistant sodium channels in human dorsal root ganglion neurons.
PG  - 117-20
AB  - Two tetrodotoxin-resistant (TTX-R) voltage-gated sodium channels, SNS and NaN,
      are preferentially expressed in small dorsal root ganglia (DRG) and trigeminal
      ganglia neurons, most of which are nociceptive, of rat and mouse. We report here 
      the sequence of NaN from human DRG, and demonstrate the presence of two TTX-R
      currents in human DRG neurons. One current has physiological properties similar
      to those reported for SNS, while the other displays hyperpolarized
      voltage-dependence and persistent kinetics; a similar TTX-R current was recently 
      identified in DRG neurons of sns-null mouse. Thus SNS and NaN channels appear to 
      produce different currents in human DRG neurons.
FAU - Dib-Hajj, S D
AU  - Dib-Hajj SD
AD  - Department of Neurology LCI 707, Yale University School of Medicine, 333 Cedar
      Street, New Haven, CT 06510, USA.
FAU - Tyrrell, L
AU  - Tyrrell L
FAU - Cummins, T R
AU  - Cummins TR
FAU - Black, J A
AU  - Black JA
FAU - Wood, P M
AU  - Wood PM
FAU - Waxman, S G
AU  - Waxman SG
LA  - eng
SI  - GENBANK/AF188679
GR  - NS09923-28/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (NAV1.8 Voltage-Gated Sodium Channel)
RN  - 0 (NAV1.9 Voltage-Gated Sodium Channel)
RN  - 0 (Neuropeptides)
RN  - 0 (SCN10A protein, human)
RN  - 0 (SCN11A protein, human)
RN  - 0 (Scn10a protein, mouse)
RN  - 0 (Scn10a protein, rat)
RN  - 0 (Scn11a protein, mouse)
RN  - 0 (Sodium Channels)
RN  - 4368-28-9 (Tetrodotoxin)
SB  - IM
MH  - Amino Acid Sequence
MH  - Electrophysiology
MH  - Ganglia, Spinal/cytology/*metabolism
MH  - Humans
MH  - In Vitro Techniques
MH  - Kinetics
MH  - Molecular Sequence Data
MH  - NAV1.8 Voltage-Gated Sodium Channel
MH  - NAV1.9 Voltage-Gated Sodium Channel
MH  - Neurons/*metabolism
MH  - Neuropeptides/drug effects/genetics/*metabolism
MH  - Sodium Channels/chemistry/drug effects/genetics/*metabolism/physiology
MH  - Tetrodotoxin/toxicity
EDAT- 1999/12/02 00:00
MHDA- 1999/12/02 00:01
CRDT- 1999/12/02 00:00
PHST- 1999/12/02 00:00 [pubmed]
PHST- 1999/12/02 00:01 [medline]
PHST- 1999/12/02 00:00 [entrez]
AID - S0014-5793(99)01519-7 [pii]
AID - 10.1016/s0014-5793(99)01519-7 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Nov 26;462(1-2):117-20. doi: 10.1016/s0014-5793(99)01519-7.