PMID- 10579975
OWN - NLM
STAT- MEDLINE
DCOM- 19991222
LR  - 20190707
IS  - 0016-5085 (Print)
IS  - 0016-5085 (Linking)
VI  - 117
IP  - 6
DP  - 1999 Dec
TI  - Coordinated expression of 3' hox genes during murine embryonal gut development:
      an enteric Hox code.
PG  - 1339-51
AB  - BACKGROUND & AIMS: Hox genes are highly conserved developmental control genes
      that may be organized and expressed in the form of a code required for correct
      morphogenesis. Little is known about their control of the embryonal gut. However,
      Hox paralogues 4 and 5, which are expressed at the sites of origin of vagal
      neural crest cells and splanchnic mesoderm, are likely to be important. We have
      studied the expression domains of these genes in the gut both spatially and
      temporally. METHODS: CD1 mice embryos of embryonic days E8.5-E17.5 were studied. 
      The spatial and temporal expression patterns of messenger RNA of Hoxa4, b4, c4,
      d4, a5, c5, and b5 homeoprotein were determined by in situ hybridization and
      immunohistochemistry in whole embryos, whole gastrointestinal tracts, and
      vibratome sections. RESULTS: There were different spatial, temporal, and
      combinatorial expression patterns in different morphological regions: foregut,
      prececal gut, cecum, and postcecal gut. Two dynamic gradients, rostral and
      caudal, were coordinated with nested expression domains along the gut primordium.
      Region-specific domains were present in the stomach and cecum. CONCLUSIONS: The
      expression patterns of genes in paralogous groups 4 and 5 suggest that they are
      organized to form a specific enteric Hox code required for correct enteric
      development.
FAU - Pitera, J E
AU  - Pitera JE
AD  - Gastroenterology Unit, Institute of Child Health, University College London,
      London, England. J.Pitera@ich.ucl.ac.uk
FAU - Smith, V V
AU  - Smith VV
FAU - Thorogood, P
AU  - Thorogood P
FAU - Milla, P J
AU  - Milla PJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Gastroenterology
JT  - Gastroenterology
JID - 0374630
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (HOXA5 protein, human)
RN  - 0 (HOXB5 protein, human)
RN  - 0 (HOXC5 protein, human)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Hoxa4 protein, mouse)
RN  - 0 (Hoxa5 protein, mouse)
RN  - 0 (Hoxb4 protein, mouse)
RN  - 0 (Hoxb5 protein, mouse)
RN  - 0 (Hoxc4 protein, mouse)
RN  - 0 (Hoxd3 protein, mouse)
RN  - 0 (Hoxd4 protein, mouse)
RN  - 0 (Phosphoproteins)
RN  - 0 (Transcription Factors)
SB  - AIM
SB  - IM
MH  - Animals
MH  - DNA-Binding Proteins/biosynthesis/genetics/metabolism
MH  - Embryonic and Fetal Development
MH  - Female
MH  - *Gene Expression
MH  - Gene Expression Profiling
MH  - *Genes, Homeobox
MH  - Homeodomain Proteins/biosynthesis/genetics/metabolism
MH  - Intestinal Mucosa/metabolism
MH  - Intestines/*embryology
MH  - Mice
MH  - Muscles/metabolism
MH  - Neurons/metabolism
MH  - *Phosphoproteins
MH  - Pregnancy
MH  - Transcription Factors/biosynthesis/genetics/metabolism
EDAT- 1999/12/02 00:00
MHDA- 1999/12/02 00:01
CRDT- 1999/12/02 00:00
PHST- 1999/12/02 00:00 [pubmed]
PHST- 1999/12/02 00:01 [medline]
PHST- 1999/12/02 00:00 [entrez]
AID - S0016508599005478 [pii]
AID - 10.1016/s0016-5085(99)70284-2 [doi]
PST - ppublish
SO  - Gastroenterology. 1999 Dec;117(6):1339-51. doi: 10.1016/s0016-5085(99)70284-2.