PMID- 10579919
OWN - NLM
STAT- MEDLINE
DCOM- 19991230
LR  - 20071114
IS  - 0014-4827 (Print)
IS  - 0014-4827 (Linking)
VI  - 253
IP  - 1
DP  - 1999 Nov 25
TI  - Signal transduction in the erythropoietin receptor system.
PG  - 143-56
AB  - Events relayed via the single transmembrane receptor for erythropoietin (Epo) are
      essential for the development of committed erythroid progenitor cells beyond the 
      colony-forming unit-erythroid stage, and this clearly involves Epo's inhibition
      of programmed cell death (PCD). Less well resolved, however, are issues regarding
      the precise nature of Epo-dependent antiapoptotic mechanisms, the extent to which
      Epo might also promote mitogenesis and/or terminal erythroid differentiation, and
      the essential vs modulatory nature of certain Epo receptor cytoplasmic
      subdomains, signal transducing factors, and downstream pathways. Accordingly,
      this review focuses on the following aspects of Epo signal transduction: (1) Epo 
      receptor/Jak2 activation mechanisms; (2) the critical vs dispensable nature of
      (P)Y sites and SH2 domain-encoding effectors in survival, growth, and
      differentiation responses; (3) primary mechanisms by which Epo inhibits PCD; (4) 
      the integration of signals relayed by coexpressed and possibly directly
      interacting cytokine receptors; and (5) predictions regarding effector function
      which are provided by the association of certain primary and familial
      polycythemias with mutated human Epo receptor forms.
CI  - Copyright 1999 Academic Press.
FAU - Wojchowski, D M
AU  - Wojchowski DM
AD  - Program in Cell & Developmental Biology, Pennsylvania State University,
      University Park, Pennsylvania, 16802, USA. dmw1@psu.edu
FAU - Gregory, R C
AU  - Gregory RC
FAU - Miller, C P
AU  - Miller CP
FAU - Pandit, A K
AU  - Pandit AK
FAU - Pircher, T J
AU  - Pircher TJ
LA  - eng
GR  - R01 DK40242/DK/NIDDK NIH HHS/United States
GR  - R01 HL4491/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Exp Cell Res
JT  - Experimental cell research
JID - 0373226
RN  - 0 (Receptors, Erythropoietin)
SB  - IM
MH  - Humans
MH  - Polycythemia/congenital/etiology
MH  - Receptor Cross-Talk
MH  - Receptors, Erythropoietin/*metabolism
MH  - *Signal Transduction
RF  - 196
EDAT- 1999/12/02 00:00
MHDA- 1999/12/02 00:01
CRDT- 1999/12/02 00:00
PHST- 1999/12/02 00:00 [pubmed]
PHST- 1999/12/02 00:01 [medline]
PHST- 1999/12/02 00:00 [entrez]
AID - 10.1006/excr.1999.4673 [doi]
AID - S0014-4827(99)94673-6 [pii]
PST - ppublish
SO  - Exp Cell Res. 1999 Nov 25;253(1):143-56. doi: 10.1006/excr.1999.4673.