PMID- 10579917
OWN - NLM
STAT- MEDLINE
DCOM- 19991230
LR  - 20091119
IS  - 0014-4827 (Print)
IS  - 0014-4827 (Linking)
VI  - 253
IP  - 1
DP  - 1999 Nov 25
TI  - Signaling via vascular endothelial growth factor receptors.
PG  - 117-30
AB  - Angiogenesis, or development of blood vessels from preexisting vasculature, has
      important functions under both normal and pathophysiological conditions. Vascular
      endothelial growth factor receptors 1-3, also known as flt-1, KDR, and flt-4, are
      endothelial cell-specific receptor tyrosine kinases which serve as key mediators 
      of the angiogenic responses. The review focuses on the signaling pathways that
      are initiated from these receptors and the recently identified VEGF coreceptor
      neuroplilin-1.
CI  - Copyright 1999 Academic Press.
FAU - Petrova, T V
AU  - Petrova TV
AD  - Molecular/Cancer Biology Laboratory, Haartman Institute, University of Helsinki, 
      Helsinki, Finland.
FAU - Makinen, T
AU  - Makinen T
FAU - Alitalo, K
AU  - Alitalo K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Exp Cell Res
JT  - Experimental cell research
JID - 0373226
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, Growth Factor)
RN  - 144713-63-3 (Neuropilin-1)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptors, Vascular Endothelial Growth Factor)
SB  - IM
MH  - Endothelium, Vascular/*physiology
MH  - Gene Expression Regulation
MH  - *Neovascularization, Pathologic
MH  - *Neovascularization, Physiologic
MH  - Nerve Tissue Proteins/*metabolism
MH  - Neuropilin-1
MH  - Receptor Protein-Tyrosine Kinases/*metabolism
MH  - Receptors, Growth Factor/*metabolism
MH  - Receptors, Vascular Endothelial Growth Factor
MH  - Signal Transduction
RF  - 173
EDAT- 1999/12/02 00:00
MHDA- 1999/12/02 00:01
CRDT- 1999/12/02 00:00
PHST- 1999/12/02 00:00 [pubmed]
PHST- 1999/12/02 00:01 [medline]
PHST- 1999/12/02 00:00 [entrez]
AID - 10.1006/excr.1999.4707 [doi]
AID - S0014-4827(99)94707-9 [pii]
PST - ppublish
SO  - Exp Cell Res. 1999 Nov 25;253(1):117-30. doi: 10.1006/excr.1999.4707.